Table IV.

Single gene false positive and negative rates

Gene False negatives Normal tissue false positives Noncancerous breast disease tissue false positives Total false positives 
HES5 0/13 (0%) 0/7 (0%) 1/5 (20%) 1/12 (8.3%) 
HSP90AA1 2/11 (18.2%) 0/6 (0%) 2/5 (40%) 2/11 (18.2%) 
TGFB3 3/14 (21.4%) 0/8 (0%) 0/5 (0%) 0/13 (0%) 
MYC 3/11 (27.3%) 0/6 (0%) 0/5 (0%) 0/11 (0%) 
ERBB2 4/14 (28.6%) 1/9 (11.1%) 3/5 (60%) 4/14 (28.6%) 
FOSL2 4/13 (30.8%) 0/7 (0%) 0/5 (0%) 0/12 (0%) 
CSF1R 4/13 (30.8%) 0/7 (0%) 0/5 (0%) 0/12 (0%) 
AKT1 5/14 (35.7%) 1/7 (14.3%) 0/5 (0%) 1/12 (8.3%) 
Total 25/103 (24.3%) 2/57 (3.5%) 6/40 (15.0%) 8/97 (8.2%) 
Gene False negatives Normal tissue false positives Noncancerous breast disease tissue false positives Total false positives 
HES5 0/13 (0%) 0/7 (0%) 1/5 (20%) 1/12 (8.3%) 
HSP90AA1 2/11 (18.2%) 0/6 (0%) 2/5 (40%) 2/11 (18.2%) 
TGFB3 3/14 (21.4%) 0/8 (0%) 0/5 (0%) 0/13 (0%) 
MYC 3/11 (27.3%) 0/6 (0%) 0/5 (0%) 0/11 (0%) 
ERBB2 4/14 (28.6%) 1/9 (11.1%) 3/5 (60%) 4/14 (28.6%) 
FOSL2 4/13 (30.8%) 0/7 (0%) 0/5 (0%) 0/12 (0%) 
CSF1R 4/13 (30.8%) 0/7 (0%) 0/5 (0%) 0/12 (0%) 
AKT1 5/14 (35.7%) 1/7 (14.3%) 0/5 (0%) 1/12 (8.3%) 
Total 25/103 (24.3%) 2/57 (3.5%) 6/40 (15.0%) 8/97 (8.2%) 

The number (and percentages) of tissues that give either a false negative or false positive result. For a false negative, a gene has a similar RRD in a cancer tissue to that of the pooled normal distribution (two-sample 1D KS test, P > 0.01). A false positive is scored when a gene has a statistically different RRD than that of the pooled normal in noncancerous breast tissues (P < 0.01).

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