Rate Constants of RyR Models Used for Simulation of Channel Activity
| Rate constant . | Model 1Ca . | Model 2Ca . | Model 3Ca . | Model 4Ca . | Model 5Ca . | Unit . |
|---|---|---|---|---|---|---|
| kon | 1.0 × 103 | 9.2 × 102 | 8.2 × 102 | 7.1 × 102 | 7.1 × 102 | μM−1· s−1 |
| koff | 1.0 × 105 | 1.4 × 104 | 5.5 × 103 | 3.0 × 103 | 2.0 × 103 | s−1 |
| kCn O1 | 1.0 × 104 | s−1 | ||||
| kCn O2 | 1.0 × 100 | s−1 | ||||
| kO1 Cn | 5.0 × 102 | s−1 | ||||
| kO2 Cn | 5.0 × 10−1 | s−1 | ||||
| kO1 Cn+1 | 2.0 × 100 | s−1 | ||||
| kCn+1 O1 | 6.7 × 10−1 | s−1 | ||||
| kO2 Cn+1 | 3.0 × 103 | s−1 | ||||
| kCn+1 O2 | 1.0 × 102 | s−1 | ||||
| kCn+1 I | 5.0 × 10−1 | s−1 | ||||
| kI Cn+1 | 1.5 × 100 | s−1 |
| Rate constant . | Model 1Ca . | Model 2Ca . | Model 3Ca . | Model 4Ca . | Model 5Ca . | Unit . |
|---|---|---|---|---|---|---|
| kon | 1.0 × 103 | 9.2 × 102 | 8.2 × 102 | 7.1 × 102 | 7.1 × 102 | μM−1· s−1 |
| koff | 1.0 × 105 | 1.4 × 104 | 5.5 × 103 | 3.0 × 103 | 2.0 × 103 | s−1 |
| kCn O1 | 1.0 × 104 | s−1 | ||||
| kCn O2 | 1.0 × 100 | s−1 | ||||
| kO1 Cn | 5.0 × 102 | s−1 | ||||
| kO2 Cn | 5.0 × 10−1 | s−1 | ||||
| kO1 Cn+1 | 2.0 × 100 | s−1 | ||||
| kCn+1 O1 | 6.7 × 10−1 | s−1 | ||||
| kO2 Cn+1 | 3.0 × 103 | s−1 | ||||
| kCn+1 O2 | 1.0 × 102 | s−1 | ||||
| kCn+1 I | 5.0 × 10−1 | s−1 | ||||
| kI Cn+1 | 1.5 × 100 | s−1 |