Table 1 Hill Equation Parameters of... | Rockefeller University Press

Table 1

Hill Equation Parameters of X-InsP₃R-1

	Ligand concentration	[ATP]	P_max	K_act	H_act	K_inh	H_inh
		mM		nM		μM
A	100 nM AdA	0.5	0.81 ± 0.03	200 ± 50	1.8 ± 0.3	45 ± 5	3.5 ± 0.4
B	10 μM InsP₃	0.5	0.81 ± 0.03	190 ± 20	1.9 ± 0.3	54 ± 6	3.9 ± 0.7
C	0.5 nM AdA	0.5	0.84 ± 0.03	250 ± 50	1.8 ± 0.3	8.9 ± 0.5	4.3 ± 0.7
D	33 nM InsP₃	0.5	0.81 ± 0.03	190 ± 20	1.9 ± 0.3	11.0 ± 1.5	3.9 ± 0.7
E	20 nM InsP₃	0.5	0.81 ± 0.03	190 ± 20	1.9 ± 0.3	0.21 ± 0.04	3.9 ± 0.7
F	10 μM InsP₃	0	0.79 ± 0.02	420 ± 40	2.2 ± 0.3	110 ± 10	4.0 ± 0.7
G	33 nM InsP₃	0	0.80 ± 0.05	540 ± 70	2.0 ± 0.3	1.4 ± 0.2	3.5 ± 0.7
H	100 nM AdA	0	0.43 ± 0.03	400 ± 50	2.4 ± 0.3	130 ± 10	4.0 ± 0.7
I	20 nM AdA	0	0.44 ± 0.03	440 ± 40	2.6 ± 0.6	9 ± 2	4.0 ± 0.7

	Ligand concentration	[ATP]	P_max	K_act	H_act	K_inh	H_inh
		mM		nM		μM
A	100 nM AdA	0.5	0.81 ± 0.03	200 ± 50	1.8 ± 0.3	45 ± 5	3.5 ± 0.4
B	10 μM InsP₃	0.5	0.81 ± 0.03	190 ± 20	1.9 ± 0.3	54 ± 6	3.9 ± 0.7
C	0.5 nM AdA	0.5	0.84 ± 0.03	250 ± 50	1.8 ± 0.3	8.9 ± 0.5	4.3 ± 0.7
D	33 nM InsP₃	0.5	0.81 ± 0.03	190 ± 20	1.9 ± 0.3	11.0 ± 1.5	3.9 ± 0.7
E	20 nM InsP₃	0.5	0.81 ± 0.03	190 ± 20	1.9 ± 0.3	0.21 ± 0.04	3.9 ± 0.7
F	10 μM InsP₃	0	0.79 ± 0.02	420 ± 40	2.2 ± 0.3	110 ± 10	4.0 ± 0.7
G	33 nM InsP₃	0	0.80 ± 0.05	540 ± 70	2.0 ± 0.3	1.4 ± 0.2	3.5 ± 0.7
H	100 nM AdA	0	0.43 ± 0.03	400 ± 50	2.4 ± 0.3	130 ± 10	4.0 ± 0.7
I	20 nM AdA	0	0.44 ± 0.03	440 ± 40	2.6 ± 0.6	9 ± 2	4.0 ± 0.7

Parameters for the biphasic Hill equations (Eq. 2) that fit the [Ca²+]_i dependence of the P_o of X-InsP₃R-1 channel under various experimental conditions.