Table 1.

Summary of genes corresponding to the hairpins identified in the ES cell screen

Number shRNA 19mer identified Matching gene Full gene name Hairpin identity Number of hairpins out of 300 Percentage of hairpins Described before? Reference 
TAGCGATGTGGTACACAGC Capn10 Calpain 10 19/19 (100%) 151 50 No  
TTTGCTTATAAGGTCACTC Fbxl12 F-box and leucine-rich repeat protein 12 19/19 (100%) 24 8.0 No  
TTGAGTGGCAATGTAACTC Ptpn11 (Shp2) Protein tyrosine phosphatase, non-receptor type 11 19/19 (100%) 19 6.3 Yes Burdon et al., 1999  
TTGCTATCCATCTCGTTAC Dusp27 Dual specificity phosphatase 27 19/19 (100%) 16 5.3 No  
TATCTGACACAACAATTGC MP1 Mus musculus similar to mitogen-activated protein kinase kinase 1–interacting protein 1 (MEK binding partner 1) 19/19 (100%) 2.6 No  
TTGACCAAGATGTTCCGAG Ephb4 Eph receptor B4 19/19 (100%) 1.0 Yes Wang et al., 2006  
TTGAATAAACTTGGTAAAC G0VN5 Mus musculus similar to putative pheromone receptor (Go-VN5) 19/19 (100%) 1.0 No  
CCCATTGAACTGCATACTA Car3 Carbonic anhydrase 3 19/19 (100%) 0.7 No  
TACTCTCTATAAGCCAGGC Abca12 ATP-binding cassette, sub-family A (ABC1), member 12, transcript variant 3 19/19 (100%) 0.7 No  
10 CATTTATGACTGAACTCTA Ccdc122 Coiled-coil domain containing 122 19/19 (100%) 0.3 No  
11 TACTAAGTAGGGCAGCTTC Mllt4 Myeloid/lymphoid or mixed-lineage leukemia 19/19 (100%) 0.3 Yes Ikeda et al., 1999  
12 GGATTATATCCATATTCAA Sism Similar to suppressor of initiator codon mutations 19/19 (100%) 0.3 No  
Number shRNA 19mer identified Matching gene Full gene name Hairpin identity Number of hairpins out of 300 Percentage of hairpins Described before? Reference 
TAGCGATGTGGTACACAGC Capn10 Calpain 10 19/19 (100%) 151 50 No  
TTTGCTTATAAGGTCACTC Fbxl12 F-box and leucine-rich repeat protein 12 19/19 (100%) 24 8.0 No  
TTGAGTGGCAATGTAACTC Ptpn11 (Shp2) Protein tyrosine phosphatase, non-receptor type 11 19/19 (100%) 19 6.3 Yes Burdon et al., 1999  
TTGCTATCCATCTCGTTAC Dusp27 Dual specificity phosphatase 27 19/19 (100%) 16 5.3 No  
TATCTGACACAACAATTGC MP1 Mus musculus similar to mitogen-activated protein kinase kinase 1–interacting protein 1 (MEK binding partner 1) 19/19 (100%) 2.6 No  
TTGACCAAGATGTTCCGAG Ephb4 Eph receptor B4 19/19 (100%) 1.0 Yes Wang et al., 2006  
TTGAATAAACTTGGTAAAC G0VN5 Mus musculus similar to putative pheromone receptor (Go-VN5) 19/19 (100%) 1.0 No  
CCCATTGAACTGCATACTA Car3 Carbonic anhydrase 3 19/19 (100%) 0.7 No  
TACTCTCTATAAGCCAGGC Abca12 ATP-binding cassette, sub-family A (ABC1), member 12, transcript variant 3 19/19 (100%) 0.7 No  
10 CATTTATGACTGAACTCTA Ccdc122 Coiled-coil domain containing 122 19/19 (100%) 0.3 No  
11 TACTAAGTAGGGCAGCTTC Mllt4 Myeloid/lymphoid or mixed-lineage leukemia 19/19 (100%) 0.3 Yes Ikeda et al., 1999  
12 GGATTATATCCATATTCAA Sism Similar to suppressor of initiator codon mutations 19/19 (100%) 0.3 No  

The total number of hairpins was 234 (78%), with other hairpins numbering 66 (22%), for a grand total of 300 (100%).

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