Table III

Intramembranous Charge Movement and Voltage Steepness of Release

(1)(2)(3)(4)(5)(6)(7)(8)
FibernAverage [CaSR]Release permeability−Q OFF(−45) mean (SEM)−Q OFF(−20) mean (SEM)Q OFF(−45) ÷ Q OFF(−20) mean (SEM)Voltage-steepness factor mean (SEM)
    μM  %/ms  nC/μF  nC/μF    mV 
[CaSR] between 1,100 and 1,900 μM         
 509971  5  1519  0.0072  19.8 (0.2)  28.2 (0.3)  0.705 (0.005)  3.50 (0.14) 
 510971  5  1412  0.0232  19.6 (0.7)  27.9 (0.7)  0.704 (0.032)  3.47 (0.06) 
 513971  3  1415  0.0048  20.0 (1.4)  30.3 (1.6)  0.659 (0.012)  3.50 (0.27) 
 514972  2  1563  0.0033  19.3 (0.5)  29.8 (0.8)  0.649 (0.0003)  3.44 (0.04) 
 515971  3  1491  0.0087  20.6 (0.2)  29.3 (0.2)  0.703 (0.002)  2.90 (0.22) 
 516972  3  1435  0.0395  25.4 (0.0)  34.2 (0.1)  0.742 (0.003)  3.47 (0.08) 
 724972  3  1526  0.0033  19.0 (0.4)  29.5 (0.2)  0.642 (0.008)  3.74 (0.42) 
 Mean    1480  0.0129  20.5  29.9  0.686  3.43 
 SEM         0.8   0.8  0.014  0.10 
[CaSR] near peak of release permeability vs. [CaSR] curve       
 509971  5   277  0.0350  19.6 (0.4)  29.1 (0.6)  0.675 (0.020)  3.09 (0.09)* 
 510971  5   304  0.1114  19.8 (0.3)  30.0 (0.9)  0.664 (0.024)  3.21 (0.09)* 
 513971  4   336  0.0268  19.6 (0.7)  28.6 (0.2)  0.684 (0.023)  3.42 (0.31) 
 514972  4   335  0.0145  20.3 (0.8)  31.0 (0.7)  0.656 (0.021)  2.77 (0.10)* 
 515971  4   270  0.0861  22.2 (0.4)*  33.8 (1.2)*  0.658 (0.011)*  2.53 (0.14) 
 516972  5   176  0.3094  24.5 (0.5)  33.8 (0.2)  0.726 (0.014)  3.76 (0.20) 
 724972  4   293  0.0149  17.2 (0.6)  27.6 (0.4)*  0.603 (0.014)  3.20 (0.18) 
 Mean     284  0.0855  20.5  30.6  0.667  3.14 
 SEM         0.9   0.9  0.014  0.15 
[CaSR] at smallest values obtained           
 509971  4    96  0.0121  19.7 (0.4)  30.6 (0.7)  0.646 (0.026)  3.62 (0.84) 
 510971  4    71  0.0270  18.1 (0.8)  28.4 (1.0)  0.638 (0.025)  3.80 (0.27) 
 513971  3    78  0.0074  19.7 (0.2)  31.9 (0.3)*  0.618 (0.006)  — 
 514972  2    94  0.0074  20.8 (1.7)  33.7 (0.8)  0.616 (0.036)  — 
 515971  4    38  0.0271  25.5 (1.3)  42.7 (2.3)*  0.599 (0.013)*  3.61 (0.41)* 
 516972  4    59  0.0487  25.3 (0.6)  34.6 (0.9)  0.733 (0.030)  3.22 (0.13) 
 724972  7    77  0.0076  18.3 (0.4)  28.8 (0.6)  0.635 (0.010)  — 
 Mean      73  0.0196  21.1  33.0  0.641  3.56 
 SEM         1.2   1.8  0.017  0.12 
(1)(2)(3)(4)(5)(6)(7)(8)
FibernAverage [CaSR]Release permeability−Q OFF(−45) mean (SEM)−Q OFF(−20) mean (SEM)Q OFF(−45) ÷ Q OFF(−20) mean (SEM)Voltage-steepness factor mean (SEM)
    μM  %/ms  nC/μF  nC/μF    mV 
[CaSR] between 1,100 and 1,900 μM         
 509971  5  1519  0.0072  19.8 (0.2)  28.2 (0.3)  0.705 (0.005)  3.50 (0.14) 
 510971  5  1412  0.0232  19.6 (0.7)  27.9 (0.7)  0.704 (0.032)  3.47 (0.06) 
 513971  3  1415  0.0048  20.0 (1.4)  30.3 (1.6)  0.659 (0.012)  3.50 (0.27) 
 514972  2  1563  0.0033  19.3 (0.5)  29.8 (0.8)  0.649 (0.0003)  3.44 (0.04) 
 515971  3  1491  0.0087  20.6 (0.2)  29.3 (0.2)  0.703 (0.002)  2.90 (0.22) 
 516972  3  1435  0.0395  25.4 (0.0)  34.2 (0.1)  0.742 (0.003)  3.47 (0.08) 
 724972  3  1526  0.0033  19.0 (0.4)  29.5 (0.2)  0.642 (0.008)  3.74 (0.42) 
 Mean    1480  0.0129  20.5  29.9  0.686  3.43 
 SEM         0.8   0.8  0.014  0.10 
[CaSR] near peak of release permeability vs. [CaSR] curve       
 509971  5   277  0.0350  19.6 (0.4)  29.1 (0.6)  0.675 (0.020)  3.09 (0.09)* 
 510971  5   304  0.1114  19.8 (0.3)  30.0 (0.9)  0.664 (0.024)  3.21 (0.09)* 
 513971  4   336  0.0268  19.6 (0.7)  28.6 (0.2)  0.684 (0.023)  3.42 (0.31) 
 514972  4   335  0.0145  20.3 (0.8)  31.0 (0.7)  0.656 (0.021)  2.77 (0.10)* 
 515971  4   270  0.0861  22.2 (0.4)*  33.8 (1.2)*  0.658 (0.011)*  2.53 (0.14) 
 516972  5   176  0.3094  24.5 (0.5)  33.8 (0.2)  0.726 (0.014)  3.76 (0.20) 
 724972  4   293  0.0149  17.2 (0.6)  27.6 (0.4)*  0.603 (0.014)  3.20 (0.18) 
 Mean     284  0.0855  20.5  30.6  0.667  3.14 
 SEM         0.9   0.9  0.014  0.15 
[CaSR] at smallest values obtained           
 509971  4    96  0.0121  19.7 (0.4)  30.6 (0.7)  0.646 (0.026)  3.62 (0.84) 
 510971  4    71  0.0270  18.1 (0.8)  28.4 (1.0)  0.638 (0.025)  3.80 (0.27) 
 513971  3    78  0.0074  19.7 (0.2)  31.9 (0.3)*  0.618 (0.006)  — 
 514972  2    94  0.0074  20.8 (1.7)  33.7 (0.8)  0.616 (0.036)  — 
 515971  4    38  0.0271  25.5 (1.3)  42.7 (2.3)*  0.599 (0.013)*  3.61 (0.41)* 
 516972  4    59  0.0487  25.3 (0.6)  34.6 (0.9)  0.733 (0.030)  3.22 (0.13) 
 724972  7    77  0.0076  18.3 (0.4)  28.8 (0.6)  0.635 (0.010)  — 
 Mean      73  0.0196  21.1  33.0  0.641  3.56 
 SEM         1.2   1.8  0.017  0.12 

The three sections of this table give results for points near the plateau level, the maximum, and the minimal levels of the release permeability vs. [CaSR] curves. Column 1 gives the fiber references. Column 2 gives the number of points used in the determinations of columns 3–8. Column 3 gives the average value of [CaSR]. Column 4 gives the average of the release permeability at −60 mV. Columns 5 and 6 give the means and SEMs of the −Q OFF values for the pulses to −45 and −20 mV, respectively (see Fig. 7). Column 7 gives the mean and SEM of the ratio of the OFF charges at −45 and −20 mV. Column 8 gives the mean and SEM of the e -fold voltage-steepness factor of the release permeability for the pulses between −70 and −60 mV as described for Fig. 8. Asterisks indicate significant difference from the corresponding average value in the previous section of the table (see text for details).  

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