Table 2.

Sequence-based neutrality tests across the 27 genes encoding the IFNs and their receptors

 AFRICA EUROPE ASIA 
Gene TD D F Hn TD D F Hn TD D F Hn 
TYPE I IFNs             
IFNA1 −0.15 0.09 0.00 −1.06 −1.59† −0.82 −1.31 −3.20* −0.97 −0.65 −0.91 −3.07* 
IFNA2 −1.42 −0.01 −0.64 −0.94 −0.02 0.41 0.31 0.90 0.54 0.12 0.31 0.20 
IFNA4 −0.88 −1.57 −1.56 −0.69 0.28 −0.97 −0.61 −2.59* 1.24 −0.68 0.04 0.43 
IFNA5 −0.93 −0.65 −0.89 0.06 −1.09 −2.42† −2.33*† −0.66 0.19 −0.42 −0.25 0.40 
IFNA6 −0.92 0.28 −0.16 0.60 −0.22 −0.31 −0.33 0.67 0.31 −0.07 0.07 0.45 
IFNA7 −1.78 −1.55 −1.94 −0.96 −1.32 −1.55 −1.74 0.27 −0.58 0.12 −0.14 −1.14 
IFNA8 −0.47 −0.11 −0.29 0.72 −0.72 −2.21† −1.99 0.47 −0.33 −0.49 −0.52 0.85 
IFNA10 −0.39 1.11 0.62 −1.81* −1.20 −0.59 −0.98 −1.95 0.86 −1.59 −0.83 −0.41 
IFNA13 0.10 1.36*† 1.09*† 0.35 −0.63 −0.65 −0.77 −1.00 −0.17 −3.01*† −2.38*† 0.09 
IFNA14 −1.70 −1.80 −2.10 −0.66 −1.37 −2.83*† −2.77*† −0.94 0.68 −0.31 0.01 0.28 
IFNA16 −1.14 0.33 −0.31 −3.40* −0.96 1.28 0.51 −4.75**† 0.67 0.27 0.49 −0.06 
IFNA17 0.21 0.68*† 0.60† −0.64 −0.06 −0.68 −0.53 −1.50 1.51 −0.82 0.07 0.27 
IFNA21 −1.12 −2.37 −2.28 0.16 0.62 0.28 0.47 0.42 0.51 0.41 0.53 −0.30 
IFNB1 −1.38 −1.06 −1.41 -0.79 −0.28 −1.25 −1.09 −1.00 −0.08 −0.42 −0.36 −0.65 
IFNE −0.51 −0.35 −0.49 0.69 −0.29 −0.42 −0.45 −0.03 0.19 −1.02 −0.71 0.08 
IFNK −0.89 −0.65 −0.89 0.08 −0.90 −1.52 −1.54 −0.53 −0.84 −3.25*† −2.81*† −0.99 
IFNW1 −1.07 −1.14 −1.33 0.61 −1.36 −3.45**† −3.20** 0.36 −0.33 −0.82 −0.77 0.76 
IFNAR1 −0.82 −0.77 −0.95 -0.27 0.46 −0.43 −0.11 1.10 −0.05 −3.50**† −2.66*† 0.75 
IFNAR2 −0.99 −2.58 −2.31 -0.71 1.03 −0.39 0.19 −0.10 −0.01 −1.76 −1.28 −0.94 
TYPE II IFN             
IFNG −1.60 −1.39 −1.76 -2.10* 0.34 −1.02 −0.65 −0.42 0.70 0.12 0.37 −0.11 
IFNGR1 −1.44 −2.13 −2.23 -0.26 0.27 −2.02 −1.43 0.44 −0.37 −0.95 -0.88 0.55 
IFNGR2 −1.13 −3.09 −2.77 -0.37 0.39 −1.63 −1.05 −0.54 −0.73 −4.08**† −3.36**† −0.92 
TYPE III IFNs             
IL28A −0.95 −1.99 −1.90 -2.50 −0.93 −1.33 −1.42 −0.05 −1.92*†† −3.39**† −3.42**† −0.89 
IL28B −0.18 1.18**† 0.75† 0.42 0.66 −1.06 −0.48 −1.73 −1.57*† −3.01*† −2.94*† −2.35* 
IL29 −1.00 −2.00 −1.95 -0.33 −1.72*† −3.81**†† −3.68**†† −1.41 −1.71*†† −0.86 −1.36 −1.56 
IL28RA −0.64 −0.93 −0.97 -0.24 −0.20 −1.52 −1.22 −0.28 -0.83 −2.63*† −2.33*† −0.19 
IL10RB −0.32 −0.63 −0.60 −0.66 1.50 −0.55 0.26 0.28 0.53 −1.32 −0.74 −0.35 
 AFRICA EUROPE ASIA 
Gene TD D F Hn TD D F Hn TD D F Hn 
TYPE I IFNs             
IFNA1 −0.15 0.09 0.00 −1.06 −1.59† −0.82 −1.31 −3.20* −0.97 −0.65 −0.91 −3.07* 
IFNA2 −1.42 −0.01 −0.64 −0.94 −0.02 0.41 0.31 0.90 0.54 0.12 0.31 0.20 
IFNA4 −0.88 −1.57 −1.56 −0.69 0.28 −0.97 −0.61 −2.59* 1.24 −0.68 0.04 0.43 
IFNA5 −0.93 −0.65 −0.89 0.06 −1.09 −2.42† −2.33*† −0.66 0.19 −0.42 −0.25 0.40 
IFNA6 −0.92 0.28 −0.16 0.60 −0.22 −0.31 −0.33 0.67 0.31 −0.07 0.07 0.45 
IFNA7 −1.78 −1.55 −1.94 −0.96 −1.32 −1.55 −1.74 0.27 −0.58 0.12 −0.14 −1.14 
IFNA8 −0.47 −0.11 −0.29 0.72 −0.72 −2.21† −1.99 0.47 −0.33 −0.49 −0.52 0.85 
IFNA10 −0.39 1.11 0.62 −1.81* −1.20 −0.59 −0.98 −1.95 0.86 −1.59 −0.83 −0.41 
IFNA13 0.10 1.36*† 1.09*† 0.35 −0.63 −0.65 −0.77 −1.00 −0.17 −3.01*† −2.38*† 0.09 
IFNA14 −1.70 −1.80 −2.10 −0.66 −1.37 −2.83*† −2.77*† −0.94 0.68 −0.31 0.01 0.28 
IFNA16 −1.14 0.33 −0.31 −3.40* −0.96 1.28 0.51 −4.75**† 0.67 0.27 0.49 −0.06 
IFNA17 0.21 0.68*† 0.60† −0.64 −0.06 −0.68 −0.53 −1.50 1.51 −0.82 0.07 0.27 
IFNA21 −1.12 −2.37 −2.28 0.16 0.62 0.28 0.47 0.42 0.51 0.41 0.53 −0.30 
IFNB1 −1.38 −1.06 −1.41 -0.79 −0.28 −1.25 −1.09 −1.00 −0.08 −0.42 −0.36 −0.65 
IFNE −0.51 −0.35 −0.49 0.69 −0.29 −0.42 −0.45 −0.03 0.19 −1.02 −0.71 0.08 
IFNK −0.89 −0.65 −0.89 0.08 −0.90 −1.52 −1.54 −0.53 −0.84 −3.25*† −2.81*† −0.99 
IFNW1 −1.07 −1.14 −1.33 0.61 −1.36 −3.45**† −3.20** 0.36 −0.33 −0.82 −0.77 0.76 
IFNAR1 −0.82 −0.77 −0.95 -0.27 0.46 −0.43 −0.11 1.10 −0.05 −3.50**† −2.66*† 0.75 
IFNAR2 −0.99 −2.58 −2.31 -0.71 1.03 −0.39 0.19 −0.10 −0.01 −1.76 −1.28 −0.94 
TYPE II IFN             
IFNG −1.60 −1.39 −1.76 -2.10* 0.34 −1.02 −0.65 −0.42 0.70 0.12 0.37 −0.11 
IFNGR1 −1.44 −2.13 −2.23 -0.26 0.27 −2.02 −1.43 0.44 −0.37 −0.95 -0.88 0.55 
IFNGR2 −1.13 −3.09 −2.77 -0.37 0.39 −1.63 −1.05 −0.54 −0.73 −4.08**† −3.36**† −0.92 
TYPE III IFNs             
IL28A −0.95 −1.99 −1.90 -2.50 −0.93 −1.33 −1.42 −0.05 −1.92*†† −3.39**† −3.42**† −0.89 
IL28B −0.18 1.18**† 0.75† 0.42 0.66 −1.06 −0.48 −1.73 −1.57*† −3.01*† −2.94*† −2.35* 
IL29 −1.00 −2.00 −1.95 -0.33 −1.72*† −3.81**†† −3.68**†† −1.41 −1.71*†† −0.86 −1.36 −1.56 
IL28RA −0.64 −0.93 −0.97 -0.24 −0.20 −1.52 −1.22 −0.28 -0.83 −2.63*† −2.33*† −0.19 
IL10RB −0.32 −0.63 −0.60 −0.66 1.50 −0.55 0.26 0.28 0.53 −1.32 −0.74 −0.35 

TD, Tajima’s D; D, Fu & Li’s D*; F, Fu & Li’s F*; Hn, normalized Fay && Wu’s H. **/*, P ≤ 0.01 and ≤ 0.05, respectively, according to the model of (Voight et al., 2005); ††/†, P ≤ 0.01 and ≤ 0.05, respectively, according to the model of (Laval et al., 2010).

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