Pulmonary genes induced by i.t. IL-13 in IL-4Rα−/−/SMP8–IL-4Rα+/− mice
| Gene | Alternate name | Description | Reference |
| Egln3 | EGL nine homologue 3 | A prolyl hydroxylase, involved in muscle differentiation, most highly expressed in muscle. | Fu et al., 2007 |
| Vcan | Versican, chondroitin sulfate glycoprotein 2 (Cspg2) | A large chondroitin sulfate proteoglycan that is deposited in the airway smooth muscle layer in patients with asthma; promotes proliferation and migration of vascular smooth muscle cells. | Huang et al., 2006 |
| Myocd | Myocardin | The dominant driver of smooth muscle differentiation and the smooth muscle contractile phenotype | Pipes et al., 2006 |
| Rab39b | Ras-related protein Rab 39B | A member of the RAS oncogene family; small molecular weight GTPases that control vesicular trafficking. Ras family signaling is associated with differentiation, proliferation, and hypertrophy. | Sugden, 2003 |
| Timp1 | Tissue inhibitor of metalloproteinase 1 | Expressed in dystrophic and regenerating muscle fibers, blocks extracellular matrix degradation. | Untergasser et al., 2005; Sun et al., 2006 |
| Tnfrsf11b | TNF receptor superfamily, member 11b, osteoprotegerin (OPG) | Produced by smooth muscle cells; stimulates proliferation and migration of pulmonary artery smooth muscle cells in vitro. | Lawrie et al., 2008 |
| Gene | Alternate name | Description | Reference |
| Egln3 | EGL nine homologue 3 | A prolyl hydroxylase, involved in muscle differentiation, most highly expressed in muscle. | Fu et al., 2007 |
| Vcan | Versican, chondroitin sulfate glycoprotein 2 (Cspg2) | A large chondroitin sulfate proteoglycan that is deposited in the airway smooth muscle layer in patients with asthma; promotes proliferation and migration of vascular smooth muscle cells. | Huang et al., 2006 |
| Myocd | Myocardin | The dominant driver of smooth muscle differentiation and the smooth muscle contractile phenotype | Pipes et al., 2006 |
| Rab39b | Ras-related protein Rab 39B | A member of the RAS oncogene family; small molecular weight GTPases that control vesicular trafficking. Ras family signaling is associated with differentiation, proliferation, and hypertrophy. | Sugden, 2003 |
| Timp1 | Tissue inhibitor of metalloproteinase 1 | Expressed in dystrophic and regenerating muscle fibers, blocks extracellular matrix degradation. | Untergasser et al., 2005; Sun et al., 2006 |
| Tnfrsf11b | TNF receptor superfamily, member 11b, osteoprotegerin (OPG) | Produced by smooth muscle cells; stimulates proliferation and migration of pulmonary artery smooth muscle cells in vitro. | Lawrie et al., 2008 |