Gene set enrichment analysis
| Pathways/signatures | References | Enriched in WT | Enriched in Nfatc1−/− B cells | Nominal P value | FDRq value |
| Cell cycle | Brentani et al., 2003 | Yes | No | <0.0001 | <0.07 |
| Cho et al., 2001 | |||||
| Whitfield et al., 2002 | |||||
| Liu et al., 2004 | |||||
| Proliferation | Shaffer et al., 2002 | Yes | No | <0.0001 | <0.09 |
| Rosenwald et al., 2002 | |||||
| Su et al., 2004 | |||||
| Myc targets | Zeller et al., 2003 | Yes | No | <0.01 | <0.08 |
| Yu et al., 2005 | |||||
| Antiapoptosis | Wu et al., 2002 | Yes | No | ≤0.01 | <0.08 |
| Wnt signaling | Kenny et al., 2005 | Yes | No | <0.031 | 0.24 |
| Pathways/signatures | References | Enriched in WT | Enriched in Nfatc1−/− B cells | Nominal P value | FDRq value |
| Cell cycle | Brentani et al., 2003 | Yes | No | <0.0001 | <0.07 |
| Cho et al., 2001 | |||||
| Whitfield et al., 2002 | |||||
| Liu et al., 2004 | |||||
| Proliferation | Shaffer et al., 2002 | Yes | No | <0.0001 | <0.09 |
| Rosenwald et al., 2002 | |||||
| Su et al., 2004 | |||||
| Myc targets | Zeller et al., 2003 | Yes | No | <0.01 | <0.08 |
| Yu et al., 2005 | |||||
| Antiapoptosis | Wu et al., 2002 | Yes | No | ≤0.01 | <0.08 |
| Wnt signaling | Kenny et al., 2005 | Yes | No | <0.031 | 0.24 |
Gene set enrichment analysis (GSEA) of microarray data of splenic B cells from WT and mb1-cre x Nfatc1flx/flx mice stimulated for 16 h by α-IgM using 81 lymphoma-associated signatures from the signature database of the Staudt laboratory (http://lymphochip.nih.gov/signaturedb) and 1.687 curated gene sets (c2) from the Molecular Signatures Database (MSigDB; Subramanian et al., 2005). All references mentioned in Table I are cited in Subramanian et al., 2005.