Table I.

Loss of infectivity of PbeIK2 (-) sporozoites in C57BL/6 mice

Infected by  Wild type PbeIK2 (-) 
  Infected/total PPDs (no. of mice) Infected/total PPDs (no. of mice) 
Mosquito bitea  6 / 6 3 (6) 0 / 6  
  6 / 6 3 (6) 1 / 16 7(1) 
Intravenous injection 10,000b 12 / 12 3(12) 5 / 12 7(2), 8(3) 
 1,000b 6 / 6 4(6) 0 / 6  
Infected by  Wild type PbeIK2 (-) 
  Infected/total PPDs (no. of mice) Infected/total PPDs (no. of mice) 
Mosquito bitea  6 / 6 3 (6) 0 / 6  
  6 / 6 3 (6) 1 / 16 7(1) 
Intravenous injection 10,000b 12 / 12 3(12) 5 / 12 7(2), 8(3) 
 1,000b 6 / 6 4(6) 0 / 6  

Pre-patent day (PPD), Number of days after sporozoite inoculation until detection of erythrocytic stages by microscopic examination of blood smears.

a

10 infected mosquitoes per mouse. Shown are results of two independent experiments.

b

No. of injected sporozoites.

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