Circulating cytokines, growth factors, and hormones in 3-d IL-1β–treated rats
| Treatment | IL-6 | IGF-1 | Corticosterone |
| pg/ml | ng/ml | ng/ml | |
| Ad lib | 106 ± 44 | 1,075 ± 63 | 48 ± 29 |
| PF | Undetectable (LOD = 62.5) | 851 ± 41* | 70 ± 27 |
| IL-1β | 102 ± 26 | 1013 ± 46 | 183 ± 40* |
| Treatment | IL-6 | IGF-1 | Corticosterone |
| pg/ml | ng/ml | ng/ml | |
| Ad lib | 106 ± 44 | 1,075 ± 63 | 48 ± 29 |
| PF | Undetectable (LOD = 62.5) | 851 ± 41* | 70 ± 27 |
| IL-1β | 102 ± 26 | 1013 ± 46 | 183 ± 40* |
Rats were infused for 3 d with IL-1β into the lateral ventricle using an osmotic minipump. Control animals were infused over the same time period with a Veh solution and were fed ad lib or PF with IL-1β–treated animals (n = 8–11/group). Plasma IL-6 and IGF-1 were measured by ELISA, and corticosterone was measured by RIA. Data are represented as mean ± SEM. *, P < 0.05 versus ad lib control as calculated by one-way ANOVA and Bonferroni’s post test or Kruskal-Wallis test and Dunn’s multiple comparison post test where appropriate.