Circulating cytokines, growth factors, and hormones in acute IL-1β–treated mice
| Treatment | IL-6 | IL-1β | IGF-1 | Corticosterone |
| pg/ml | pg/ml | ng/ml | ng/ml | |
| 2-h Veh | 13 ± 3 | 22 ± 6 | 225 ± 11 | 104 ± 16 |
| 2-h 10-ng IL-1β | 298 ± 35*** | 25 ± 6 | 216 ± 18 | 397 ± 30*** |
| 4-h Veh | 21 ± 6 | 16 ± 3 | 200 ± 8 | 103 ± 14 |
| 4-h 10-ng IL-1β | 69 ± 14 | 28 ± 6 | 168 ± 9 | 258 ± 35*** |
| 8-h Veh | 13 ± 6 | 46 ± 15 | 173 ± 4 | 115 ± 34 |
| 8-h 10-ng IL-1β | 8 ± 2 | 32 ± 5 | 205 ± 6 | 72 ± 10 |
| Treatment | IL-6 | IL-1β | IGF-1 | Corticosterone |
| pg/ml | pg/ml | ng/ml | ng/ml | |
| 2-h Veh | 13 ± 3 | 22 ± 6 | 225 ± 11 | 104 ± 16 |
| 2-h 10-ng IL-1β | 298 ± 35*** | 25 ± 6 | 216 ± 18 | 397 ± 30*** |
| 4-h Veh | 21 ± 6 | 16 ± 3 | 200 ± 8 | 103 ± 14 |
| 4-h 10-ng IL-1β | 69 ± 14 | 28 ± 6 | 168 ± 9 | 258 ± 35*** |
| 8-h Veh | 13 ± 6 | 46 ± 15 | 173 ± 4 | 115 ± 34 |
| 8-h 10-ng IL-1β | 8 ± 2 | 32 ± 5 | 205 ± 6 | 72 ± 10 |
WT mice received i.c.v. injections of IL-1β. Animals were sacrificed at 2, 4, and 8 h after the injection (n = 6-9/group). Plasma IL-6, IL-1β, and IGF-1 levels were measured by ELISA and corticosterone was measured by RIA. ***, P < 0.001 versus corresponding Veh-injected control as calculated by two-way ANOVA with Bonferroni’s post test.