Table II.

Phenotype of cDCs and pDCs in pancreatic LNs from LCMV-infected Vα14 Ins-NP mice

Cell surface marker cDCs (CD11c+120G8pDCs (CD11c+120G8+
 Day 0 Day 6 Fold change Day 0 Day 6 Fold change 
CD80 255 ± 20 462 ± 11a 1.81 204 ± 36 405 ± 18a 1.98 
CD86 325 ± 33 543 ± 18a 1.67 285 ± 19 475 ± 31a 1.67 
CD40 240 ± 18 470 ± 41a 1.95 125 ± 12 350 ± 20a 2.80 
I-Ag7 (MHC class II) 824 ± 45 1,180 ± 37a 1.43 201 ± 43 274 ± 51a 1.36 
PD-L1 582 ± 23 1,056 ± 27a 1.81 219 ± 25 738 ± 35a 3.37 
Cell surface marker cDCs (CD11c+120G8pDCs (CD11c+120G8+
 Day 0 Day 6 Fold change Day 0 Day 6 Fold change 
CD80 255 ± 20 462 ± 11a 1.81 204 ± 36 405 ± 18a 1.98 
CD86 325 ± 33 543 ± 18a 1.67 285 ± 19 475 ± 31a 1.67 
CD40 240 ± 18 470 ± 41a 1.95 125 ± 12 350 ± 20a 2.80 
I-Ag7 (MHC class II) 824 ± 45 1,180 ± 37a 1.43 201 ± 43 274 ± 51a 1.36 
PD-L1 582 ± 23 1,056 ± 27a 1.81 219 ± 25 738 ± 35a 3.37 

MFI was assessed on DC subsets in pancreatic LNs of Ins-NP Vα14 mice before and 6 d after LCMV infection. Results correspond to means ± SD of values obtained in four independent experiments with three pooled mice per group.

a

P < 0.05 for day 6 compared with day 0.

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