Inhibition of HIV-1 infection with NL-LucR.T2A-BaL.ecto by mAbs in intact PBMC and PBMC cell subsets
| mAb | Target cell populationsa | ||||
| Intact PBMC | CD4+ T cells | CD4+ T cell-depleted PBMC | CD14+ monocytes | CD14+ monocyte-depleted PBMC | |
| µg/ml | µg/ml | µg/ml | µg/ml | µg/ml | |
| PGN632 | 0.29 | >50 | 0.31 | 0.18 | >50 |
| IgG1b12 | 6.2 | 4.6 | 0.57 | 0.65 | 5.1 |
| 2G12 | 0.39 | 4.6 | 0.06 | 0.03 | 5.0 |
| 4E10 | 40 | 41 | 47 | 32 | 42 |
| mAb | Target cell populations | ||||
| Intact PBMC | CD4+ T cells | CD4+ T cell-depleted PBMC | CD14+ monocytes | CD14+ monocyte-depleted PBMC | |
| PGN632 | 0.29 | >50 | 0.31 | 0.18 | >50 |
| IgG1b12 | 6.2 | 4.6 | 0.57 | 0.65 | 5.1 |
| 2G12 | 0.39 | 4.6 | 0.06 | 0.03 | 5.0 |
| 4E10 | 40 | 41 | 47 | 32 | 42 |
Target cell populations are IC80 values
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