Table IV. Breadth of anti-phospholipid... | Rockefeller University Press

Table IV.

Breadth of anti-phospholipid mAb inhibition of HIV-1 infectivity against R5 and R5/X4 replicating HIV-1 Renilla reporter viruses engineered to express five transmitted/founder env genes, B.BaL env, and B.SF162LS env in the PBMC infectivity assay

HIV-1 genes in NL-LucR.T2A-ENV.ecto viruses^a	mAbs^b						Coreceptor usage
	IS4	CL1	P1	PGN632	Anti-RSV	4E10
	µg/ml	µg/ml	µg/ml	µg/ml	µg/ml	µg/ml
B.BaL	0.58	2.2	0.11	<0.02	>50	1.6	CCR5
B.WITO	0.06	<0.02	<0.02	<0.02	>50	0.16	CCR5
B.CH040	<0.02	<0.02	<0.02	<0.02	>50	<0.02	CCR5
B.CH058	0.37	0.17	0.29	<0.02	>50	3.6	CCR5
B.CH077	16	46	5.5	0.07	>50	3.0	CCR5
B.SF162LS	1.5	2.6	0.4	<0.02	>50	2.5	CCR5
B.WEAU410	>50	>50	>50	>50	>50	4.5	CXCR4/CCR5

HIV-1 genes in NL-LucR.T2A-ENV.ecto viruses^a	mAbs^b						Coreceptor usage
	IS4	CL1	P1	PGN632	Anti-RSV	4E10
	µg/ml	µg/ml	µg/ml	µg/ml	µg/ml	µg/ml
B.BaL	0.58	2.2	0.11	<0.02	>50	1.6	CCR5
B.WITO	0.06	<0.02	<0.02	<0.02	>50	0.16	CCR5
B.CH040	<0.02	<0.02	<0.02	<0.02	>50	<0.02	CCR5
B.CH058	0.37	0.17	0.29	<0.02	>50	3.6	CCR5
B.CH077	16	46	5.5	0.07	>50	3.0	CCR5
B.SF162LS	1.5	2.6	0.4	<0.02	>50	2.5	CCR5
B.WEAU410	>50	>50	>50	>50	>50	4.5	CXCR4/CCR5

Transmitted env genes were derived from patients WITO4160, 700-01-004-0, 700-01-005-8, 700-01-007-7, and WEAu0575, respectively.

mAbs are shown as IC₈₀ values.

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