Clinical characteristics of patients
| Normotensive (n = 12) | Preeclamptic (n = 12) | |
| Maternal age (yr) | 24 ± 4.71 | 28.42 ± 6.13 |
| Gestation age (wk) | 38.63 ± 0.98 | 31.21 ± 2.8 |
| Primigravid (%) | 33 | 25 |
| Systolic blood pressure (mmHg) | 118.2 ± 4.97 | 181.3 ± 16.93* |
| Diastolic blood pressure (mmHg) | 67.33 ± 6.21 | 106.8 ± 13.22* |
| Proteinuria (mg/24 h) | <300 | 554.5 ± 800.7 |
| Fetal weight (g) | 3,347 ± 429 | 1,437 ± 390 |
| Weight by gestational age (percentile) | 58.1 ± 31 | 20.2 ± 18* |
| Number of babies born at <10th percentile (n [%]) | 1 (8%) | 6 (50%)* |
| Luciferase activity of patient serum (fold induction) | 1.64 ± 0.97 | 7.68 ± 0.34* |
| Normotensive (n = 12) | Preeclamptic (n = 12) | |
| Maternal age (yr) | 24 ± 4.71 | 28.42 ± 6.13 |
| Gestation age (wk) | 38.63 ± 0.98 | 31.21 ± 2.8 |
| Primigravid (%) | 33 | 25 |
| Systolic blood pressure (mmHg) | 118.2 ± 4.97 | 181.3 ± 16.93* |
| Diastolic blood pressure (mmHg) | 67.33 ± 6.21 | 106.8 ± 13.22* |
| Proteinuria (mg/24 h) | <300 | 554.5 ± 800.7 |
| Fetal weight (g) | 3,347 ± 429 | 1,437 ± 390 |
| Weight by gestational age (percentile) | 58.1 ± 31 | 20.2 ± 18* |
| Number of babies born at <10th percentile (n [%]) | 1 (8%) | 6 (50%)* |
| Luciferase activity of patient serum (fold induction) | 1.64 ± 0.97 | 7.68 ± 0.34* |
This table illustrates the key differences between the two patient populations used in the experiments. The preeclamptic women demonstrate increased blood pressure, proteinuria, and luciferase activity, which reflects the biological activity of AT1-AA. 6 out of the 12 babies (50%) born to the preeclamptic cohort weighed <10th percentile for their gestational age, whereas only 1 out of 12 of babies (8%) born to the normotensive cohort were considered IUGR. *, P < 0.05.