Table I. Functional αβ T cells are... | Rockefeller University Press

Table I.

Functional αβ⁺ T cells are required for regulating Ctla4^−/− T cells in mixed BM chimaeras

Source of regulatory cells^a	Rescue frequency^b
TCRd^−/−:Ctla4^−/−	6/6
TCRb^−/−:Ctla4^−/−	0/5
Cd4^−/−:Ctla4^−/−	7/8
Cd8^−/−:Ctla4^−/−	4/5
Cd28^−/−:Ctla4^−/−	0/15
wt:B7^−/−Ctla4^−/−	4/4

Source of regulatory cells^a	Rescue frequency^b
TCRd^−/−:Ctla4^−/−	6/6
TCRb^−/−:Ctla4^−/−	0/5
Cd4^−/−:Ctla4^−/−	7/8
Cd8^−/−:Ctla4^−/−	4/5
Cd28^−/−:Ctla4^−/−	0/15
wt:B7^−/−Ctla4^−/−	4/4

1:1 mixed BM chimaeras of indicated genotypes, except for those involving Cd28^−/− BM cells where some were at a 3:1 ratio (n = 5). Control mixed chimaeras receiving Ctla4+/+ instead of Ctla4^−/− BM remained healthy (not depicted).

Frequency of surviving mice with quiescent Ctla4^-/- T cells.

View Large

This Feature Is Available To Subscribers Only