Induction of autoimmune lesions
| Donor cells | Mice | Incidence |
|---|---|---|
| Spleen cells (5×106) | WT | 0/4 |
| RbAp48-Tg | 0/4 | |
| cLN cells (5×106) | WT | 0/5 |
| RbAp48-Tg | 4/5 | |
| cLN T cells (5×106) | WT | 0/4 |
| RbAp48-Tg | 0/5 | |
| cLN B cells (5×106) | WT | 0/4 |
| RbAp48-Tg | 0/4 |
| Donor cells | Mice | Incidence |
|---|---|---|
| Spleen cells (5×106) | WT | 0/4 |
| 0/4 | ||
| cLN cells (5×106) | WT | 0/5 |
| 4/5 | ||
| cLN T cells (5×106) | WT | 0/4 |
| 0/5 | ||
| cLN B cells (5×106) | WT | 0/4 |
| 0/4 |
Whole spleen, cLN cells, cLN T cells, or cLN B cells were transferred intravenously into Rag2−/− mice. The host mice were killed 6 wk after transfer. Inflammatory lesions of salivary or lacrimal glands were evaluated by pathological analysis.
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