Univariate and multivariate analyses of factors associated with survival and recurrence
| OS | DFS | |||||||
| Univariate | Multivariate | Univariate | Multivariate | |||||
| Variables | p-value | HR | 95% CI | p-value | p-value | HR | 95% CI | p-value |
| Age, years (>48 vs. ≤48) | 0.344 | NA | 0.643 | NA | ||||
| Gender (female vs. male) | 0.461 | NA | 0.215 | NA | ||||
| HbsAg (positive vs. negative) | 0.086 | NA | 0.127 | NA | ||||
| Cirrhosis (present vs. absent) | 0.211 | NA | 0.09 | NA | ||||
| ALT, U/L (>42 vs. ≤42) | 0.38 | NA | 0.883 | NA | ||||
| AFP, ng/ml (>25 vs. ≤25) | 0.005 | 1.68 | 1.07–2.62 | 0.023 | 0.221 | NA | ||
| Tumor size, cm (>5 vs. ≤5) | 0.004 | 1.66 | 1.1–2.51 | 0.016 | 0.024 | 1.44 | 1–2.07 | 0.052 |
| Tumor multiplicity (multiple vs. solitary) | <0.001 | 1.32 | 0.61–2.84 | 0.485 | 0.017 | 1.11 | 0.55–2.23 | 0.773 |
| Vascular invasion (present vs. absent) | 0.002 | 2.1 | 1.19–3.74 | 0.011 | 0.006 | 1.88 | 1.1–3.23 | 0.022 |
| Intrahepatic metastasis (yes vs. no) | <0.001 | 2.18 | 1.06–4.5 | 0.035 | 0.007 | 1.58 | 0.79–3.16 | 0.195 |
| TNM stage (III+IV vs. I+II) | 0.014 | 0.68 | 0.37–1.26 | 0.219 | 0.034 | 0.96 | 0.56–1.63 | 0.869 |
| Tumor differentiation (III+IV vs. I+II) | 0.1 | NA | 0.308 | NA | ||||
| Fibrous capsule (present vs. absent) | 0.263 | NA | 0.742 | NA | ||||
| Peritumoral stroma Mϕ (high vs. low) | <0.001 | 1.67 | 1.15–2.42 | 0.007 | 0.003 | 1.33 | 0.94–1.88 | 0.113 |
| OS | DFS | |||||||
| Univariate | Multivariate | Univariate | Multivariate | |||||
| Variables | p-value | HR | 95% CI | p-value | p-value | HR | 95% CI | p-value |
| Age, years (>48 vs. ≤48) | 0.344 | NA | 0.643 | NA | ||||
| Gender (female vs. male) | 0.461 | NA | 0.215 | NA | ||||
| HbsAg (positive vs. negative) | 0.086 | NA | 0.127 | NA | ||||
| Cirrhosis (present vs. absent) | 0.211 | NA | 0.09 | NA | ||||
| ALT, U/L (>42 vs. ≤42) | 0.38 | NA | 0.883 | NA | ||||
| AFP, ng/ml (>25 vs. ≤25) | 0.005 | 1.68 | 1.07–2.62 | 0.023 | 0.221 | NA | ||
| Tumor size, cm (>5 vs. ≤5) | 0.004 | 1.66 | 1.1–2.51 | 0.016 | 0.024 | 1.44 | 1–2.07 | 0.052 |
| Tumor multiplicity (multiple vs. solitary) | <0.001 | 1.32 | 0.61–2.84 | 0.485 | 0.017 | 1.11 | 0.55–2.23 | 0.773 |
| Vascular invasion (present vs. absent) | 0.002 | 2.1 | 1.19–3.74 | 0.011 | 0.006 | 1.88 | 1.1–3.23 | 0.022 |
| Intrahepatic metastasis (yes vs. no) | <0.001 | 2.18 | 1.06–4.5 | 0.035 | 0.007 | 1.58 | 0.79–3.16 | 0.195 |
| TNM stage (III+IV vs. I+II) | 0.014 | 0.68 | 0.37–1.26 | 0.219 | 0.034 | 0.96 | 0.56–1.63 | 0.869 |
| Tumor differentiation (III+IV vs. I+II) | 0.1 | NA | 0.308 | NA | ||||
| Fibrous capsule (present vs. absent) | 0.263 | NA | 0.742 | NA | ||||
| Peritumoral stroma Mϕ (high vs. low) | <0.001 | 1.67 | 1.15–2.42 | 0.007 | 0.003 | 1.33 | 0.94–1.88 | 0.113 |
Cox proportional hazards regression model. Variables used in multivariate analysis were adopted by univariate analysis. The underlined terms represent statistical significance. AFP, α-fetoprotein; ALT, alanine aminotransferase; CI, confidence interval; HbsAg, hepatitis B surface antigen; HR, hazard ratio; NA, not adopted; TNM, tumor node metastasis.