Table IV. Correlations with micro- and... | Rockefeller University Press

Table IV.

Correlations with micro- and macropathogen richness for SNPs associated with different traits

SNP	Gene/location	Allele		Micropathogen		Macropathogen		Trait/disease
		Risk	Anc.^a	τ^b	P-value^c	τ^b	P-value^c
rs6897932	IL7R	C	C	0.22	n.s.^d	0.21	n.s.^d	Multiple sclerosis/Type 1 diabetes
rs917997	IL18RAP (downstream)	A	G	0.42	<0.001	0.35	0.008	CeD/IBD
rs10045431	IL12B	C	C	0.43	<0.001	0.34	0.015	CD
rs7517847	IL23R	C	A	0.23	n.s.^d	0.26	n.s.^d	IBD
rs11209026	IL23R	G	G	0.47	<0.001	0.44	0.001	IBD
rs11465804	IL23R	T	T	0.39	0.004	0.44	<0.001	CD
rs6822844	IL2/IL21 (intergenic)	G	G	0.40	0.004	0.39	0.006	CeD
rs3024505	IL10	T	C	−0.28	n.s.^d	−0.28	n.s.^d	Ulcerative colitis
rs17810546	IL12A	G	A	0.03	n.s.^d	−0.11	n.s.^d	CeD
rs13015714	IL18R1	C	A	0.47	<0.001	0.39	0.002	CeD
rs2250417	IL18	A	A	0.23	n.s.^d	0.26	n.s.^d	Protein quantitative trait loci
rs7626795	IL1RAP	G	A	0.20	n.s.^d	0.04	n.s.^d	Lung cancer
rs4129267	IL6R	C	C	−0.17	n.s.^d	−0.24	n.s.^d	Protein quantitative trait loci/pulmonary function
rs6761276	IL1F10^e	n.r.^f	T	−0.31	0.030	−0.51	<0.001	Protein quantitative trait loci
rs12251307	IL2RA	T	T	−0.16	n.s.^d	−0.13	n.s.^d	Type 1 diabetes

SNP	Gene/location	Allele		Micropathogen		Macropathogen		Trait/disease
		Risk	Anc.^a	τ^b	P-value^c	τ^b	P-value^c
rs6897932	IL7R	C	C	0.22	n.s.^d	0.21	n.s.^d	Multiple sclerosis/Type 1 diabetes
rs917997	IL18RAP (downstream)	A	G	0.42	<0.001	0.35	0.008	CeD/IBD
rs10045431	IL12B	C	C	0.43	<0.001	0.34	0.015	CD
rs7517847	IL23R	C	A	0.23	n.s.^d	0.26	n.s.^d	IBD
rs11209026	IL23R	G	G	0.47	<0.001	0.44	0.001	IBD
rs11465804	IL23R	T	T	0.39	0.004	0.44	<0.001	CD
rs6822844	IL2/IL21 (intergenic)	G	G	0.40	0.004	0.39	0.006	CeD
rs3024505	IL10	T	C	−0.28	n.s.^d	−0.28	n.s.^d	Ulcerative colitis
rs17810546	IL12A	G	A	0.03	n.s.^d	−0.11	n.s.^d	CeD
rs13015714	IL18R1	C	A	0.47	<0.001	0.39	0.002	CeD
rs2250417	IL18	A	A	0.23	n.s.^d	0.26	n.s.^d	Protein quantitative trait loci
rs7626795	IL1RAP	G	A	0.20	n.s.^d	0.04	n.s.^d	Lung cancer
rs4129267	IL6R	C	C	−0.17	n.s.^d	−0.24	n.s.^d	Protein quantitative trait loci/pulmonary function
rs6761276	IL1F10^e	n.r.^f	T	−0.31	0.030	−0.51	<0.001	Protein quantitative trait loci
rs12251307	IL2RA	T	T	−0.16	n.s.^d	−0.13	n.s.^d	Type 1 diabetes

Ancestral state based on chimpanzee sequence.

The correlation coefficient is calculated between pathogen richness and the risk allele frequency;.

Bonferroni-corrected p-value (15 tests).

Nonsignificant (P > 0.05).

This SNP is located within IL1F10, but affects IL1RN protein levels.

Not reported.