Table I.

Correlations with micro- and macropathogen richness

SNP Gene Micropathogens Macropathogens 
  τ P-value (corrected)a Rankb τ P-value (corrected)a Rankb 
rs17561 IL1A 0.38 0.151 0.854 0.47 0.006 0.937 
rs1143634 IL1B 0.55 <0.0001 0.996 0.58 <0.0001 0.996 
rs6761276 IL1F10 −0.31 2.011 0.740 −0.51 0.001 0.980 
rs10496447 IL1F8 0.54 <0.0001 0.995 0.57 <0.0001 0.994 
rs3917304 IL1R1 −0.53 <0.0001 0.994 −0.51 <0.0001 0.979 
rs6444444 IL1RAP −0.55 <0.0001 0.998 −0.50 0.003 0.969 
rs6800609 IL1RAP 0.39 0.092 0.865 0.47 0.005 0.930 
rs2885373 IL1RAP 0.55 <0.0001 0.998 0.50 0.003 0.969 
rs17196143 IL1RAP −0.49 0.003 0.974 −0.51 0.002 0.966 
rs6444435 IL1RAP −0.47 0.003 0.972 −0.54 <0.0001 0.989 
rs6630730 IL1RAPL1 −0.41 0.079 0.883 −0.53 <0.0001 0.980 
rs7052954 IL1RAPL1 −0.48 0.009 0.970 −0.52 0.002 0.976 
rs6526833 IL1RAPL1 0.43 0.020 0.923 0.52 <0.0001 0.982 
rs7890572 IL1RAPL1 0.44 0.054 0.917 0.50 0.007 0.951 
rs10521948 IL1RAPL1 0.49 0.003 0.974 0.54 <0.0001 0.988 
rs7056388 IL1RAPL1 0.41 0.131 0.875 0.51 0.003 0.964 
rs196990 IL1RAPL1 0.41 0.057 0.899 0.56 <0.0001 0.994 
rs7881819 IL1RAPL1 0.38 0.406 0.830 0.51 0.003 0.966 
rs10521946 IL1RAPL1 −0.49 0.003 0.974 −0.62 <0.0001 0.999 
rs1318832 IL1RAPL1 −0.51 <0.0001 0.987 −0.55 <0.0001 0.995 
rs5943559 IL1RAPL1 −0.45 0.007 0.955 −0.56 <0.0001 0.995 
rs12387961 IL1RAPL1 0.37 0.261 0.832 0.46 0.009 0.928 
rs721953 IL1RAPL2 0.46 0.004 0.967 0.44 0.017 0.918 
rs1384360 IL1RAPL2 −0.45 0.009 0.952 −0.44 0.018 0.908 
rs6621992 IL1RAPL2 −0.45 0.010 0.955 −0.46 0.008 0.940 
rs7583215 IL1RL2 −0.55 <0.0001 0.996 −0.54 <0.0001 0.991 
rs2287041 IL1RL2 0.51 <0.0001 0.985 0.47 0.004 0.945 
rs3771188 IL1RL2 −0.54 <0.0001 0.993 −0.52 <0.0001 0.976 
rs315931 IL1RN −0.41 0.040 0.916 −0.46 0.007 0.941 
rs2637988 IL1RN −0.44 0.011 0.953 −0.47 0.004 0.954 
rs2029582 IL1RN −0.30 2.565 0.728 −0.46 0.008 0.936 
rs3087266 IL1RN −0.34 0.728 0.780 −0.46 0.008 0.928 
rs2386841 IL2RA 0.48 0.002 0.970 0.47 0.004 0.942 
rs11256497 IL2RA −0.49 0.002 0.973 −0.49 0.002 0.953 
rs2284034 IL2RB 0.37 0.244 0.834 0.48 0.003 0.950 
rs1003694 IL2RB 0.32 1.570 0.734 0.46 0.006 0.936 
rs228966 IL2RB −0.32 1.705 0.757 −0.48 0.003 0.963 
rs2284033 IL2RB 0.37 0.245 0.853 0.56 <0.0001 0.996 
rs228973 IL2RB 0.44 0.012 0.943 0.52 <0.0001 0.980 
rs228975 IL2RB −0.49 0.001 0.980 −0.59 <0.0001 0.999 
rs2235330 IL2RB 0.41 0.059 0.889 0.54 <0.0001 0.987 
rs2243268 IL4 −0.51 <0.0001 0.987 −0.58 <0.0001 0.997 
rs2243288 IL4 −0.43 0.021 0.932 −0.47 0.004 0.948 
rs2243290 IL4 0.49 0.001 0.978 0.54 <0.0001 0.991 
rs2070874 IL4 −0.50 0.001 0.984 −0.55 <0.0001 0.993 
rs3024672 IL4R −0.40 0.189 0.866 −0.53 0.001 0.975 
rs3024607 IL4R −0.48 0.006 0.974 −0.53 0.001 0.987 
rs17026370 IL5RA 0.47 0.011 0.951 0.55 <0.0001 0.990 
rs2066992 IL6 −0.41 0.049 0.899 −0.46 0.006 0.933 
rs2069835 IL6 −0.46 0.021 0.949 −0.53 0.002 0.982 
rs17505589 IL7 0.50 0.006 0.986 0.43 0.115 0.851 
rs11567697 IL7R 0.43 0.086 0.904 0.51 0.005 0.972 
rs1554286 IL10 −0.45 0.006 0.956 −0.56 <0.0001 0.994 
rs3024490 IL10 −0.39 0.103 0.880 −0.52 <0.0001 0.988 
rs2512144 IL10RA −0.38 0.343 0.832 −0.47 0.009 0.938 
rs999261 IL10RB 0.39 0.140 0.854 0.49 0.002 0.958 
rs2243115 IL12A −0.46 0.008 0.952 −0.43 0.045 0.843 
rs17129789 IL12RB2 −0.43 0.026 0.910 −0.51 0.001 0.971 
rs10521698 IL13RA2 −0.40 0.164 0.860 −0.50 0.003 0.956 
rs1589241 IL15 0.48 0.005 0.970 0.48 0.006 0.950 
rs2322262 IL15 0.47 0.008 0.962 0.49 0.005 0.953 
rs13106911 IL15 −0.36 0.361 0.811 −0.46 0.007 0.925 
rs8177636 IL15RA 0.39 0.179 0.858 0.47 0.006 0.942 
rs8177685 IL15RA −0.41 0.057 0.881 −0.47 0.004 0.931 
rs3136614 IL15RA −0.47 0.005 0.957 −0.40 0.125 0.798 
rs2296139 IL15RA 0.44 0.011 0.933 0.53 <0.0001 0.985 
rs12437819 IL16 −0.50 0.001 0.981 −0.41 0.071 0.846 
rs12438640 IL16 0.50 0.001 0.982 0.41 0.060 0.854 
rs10484879 IL17A −0.49 0.008 0.970 −0.39 0.425 0.770 
rs6518661 IL17RA −0.45 0.009 0.944 −0.43 0.026 0.896 
rs879576 IL17RA 0.45 0.025 0.931 0.50 0.004 0.953 
rs999514 IL17RB 0.47 0.004 0.964 0.45 0.015 0.916 
rs708567 IL17RC −0.40 0.066 0.890 −0.51 0.001 0.976 
rs6445854 IL17RD −0.43 0.030 0.912 −0.52 <0.0001 0.982 
rs4535195 IL17RD −0.44 0.013 0.942 −0.48 0.003 0.957 
rs12487790 IL17RD 0.43 0.018 0.935 0.52 <0.0001 0.983 
rs17216900 IL17RD 0.45 0.009 0.946 0.36 0.368 0.779 
rs12496746 IL17RD −0.46 0.006 0.951 −0.42 0.048 0.866 
rs455863 IL17RE −0.46 0.005 0.957 −0.57 <0.0001 0.996 
rs279581 IL17RE 0.39 0.116 0.878 0.50 0.001 0.974 
rs279572 IL17RE 0.37 0.208 0.854 0.48 0.002 0.960 
rs172155 IL17RE −0.37 0.244 0.847 −0.48 0.003 0.953 
rs2272128 IL18RAP −0.47 0.004 0.965 -0.39 0.125 0.829 
rs2243193 IL19 0.42 0.031 0.919 0.50 0.001 0.973 
rs12044804 IL19 −0.48 0.002 0.973 −0.62 <0.0001 1.000 
rs4845143 IL19 0.41 0.042 0.910 0.49 0.001 0.969 
rs12409415 IL19 −0.45 0.012 0.928 −0.49 0.002 0.945 
rs12046559 IL19 0.43 0.021 0.923 0.54 <0.0001 0.989 
rs12145973 IL19 0.59 <0.0001 1.000 0.42 0.106 0.820 
rs2138992 IL19 0.46 0.006 0.959 0.52 <0.0001 0.984 
rs2232360 IL20 −0.38 0.166 0.858 −0.46 0.007 0.934 
rs1322393 IL20RA 0.39 0.098 0.876 0.49 0.002 0.963 
rs1322394 IL20RA −0.38 0.206 0.844 −0.48 0.003 0.948 
rs75977 IL20RB -0.43 0.019 0.934 −0.47 0.005 0.940 
rs835634 IL20RB 0.43 0.020 0.932 0.46 0.008 0.929 
rs747842 IL20RB 0.43 0.023 0.929 0.46 0.008 0.930 
rs12934152 IL21R −0.57 <0.0001 0.999 −0.50 0.005 0.952 
rs10903022 IL22RA1 −0.42 0.037 0.920 −0.49 0.002 0.971 
rs10751768 IL22RA1 0.42 0.030 0.926 0.50 0.001 0.974 
rs3795302 IL22RA1 0.39 0.087 0.898 0.49 0.001 0.971 
rs4486393 IL22RA1 0.39 0.146 0.863 0.50 0.002 0.968 
rs4292900 IL22RA1 0.40 0.109 0.882 0.47 0.005 0.947 
rs16829209 IL22RA1 0.39 0.156 0.856 0.50 0.002 0.959 
rs11570915 IL26 0.40 0.132 0.852 0.53 0.001 0.980 
rs3814240 IL26 0.42 0.026 0.929 0.49 0.002 0.964 
rs3814241 IL26 0.50 0.001 0.982 0.47 0.004 0.946 
rs10878789 IL26 0.47 0.004 0.962 0.41 0.052 0.868 
rs9632389 IL31RA −0.48 0.005 0.960 −0.43 0.058 0.837 
rs10055201 IL31RA 0.39 0.120 0.869 0.45 0.009 0.927 
rs1554999 IL32 −0.48 0.002 0.965 −0.55 <0.0001 0.988 
SNP Gene Micropathogens Macropathogens 
  τ P-value (corrected)a Rankb τ P-value (corrected)a Rankb 
rs17561 IL1A 0.38 0.151 0.854 0.47 0.006 0.937 
rs1143634 IL1B 0.55 <0.0001 0.996 0.58 <0.0001 0.996 
rs6761276 IL1F10 −0.31 2.011 0.740 −0.51 0.001 0.980 
rs10496447 IL1F8 0.54 <0.0001 0.995 0.57 <0.0001 0.994 
rs3917304 IL1R1 −0.53 <0.0001 0.994 −0.51 <0.0001 0.979 
rs6444444 IL1RAP −0.55 <0.0001 0.998 −0.50 0.003 0.969 
rs6800609 IL1RAP 0.39 0.092 0.865 0.47 0.005 0.930 
rs2885373 IL1RAP 0.55 <0.0001 0.998 0.50 0.003 0.969 
rs17196143 IL1RAP −0.49 0.003 0.974 −0.51 0.002 0.966 
rs6444435 IL1RAP −0.47 0.003 0.972 −0.54 <0.0001 0.989 
rs6630730 IL1RAPL1 −0.41 0.079 0.883 −0.53 <0.0001 0.980 
rs7052954 IL1RAPL1 −0.48 0.009 0.970 −0.52 0.002 0.976 
rs6526833 IL1RAPL1 0.43 0.020 0.923 0.52 <0.0001 0.982 
rs7890572 IL1RAPL1 0.44 0.054 0.917 0.50 0.007 0.951 
rs10521948 IL1RAPL1 0.49 0.003 0.974 0.54 <0.0001 0.988 
rs7056388 IL1RAPL1 0.41 0.131 0.875 0.51 0.003 0.964 
rs196990 IL1RAPL1 0.41 0.057 0.899 0.56 <0.0001 0.994 
rs7881819 IL1RAPL1 0.38 0.406 0.830 0.51 0.003 0.966 
rs10521946 IL1RAPL1 −0.49 0.003 0.974 −0.62 <0.0001 0.999 
rs1318832 IL1RAPL1 −0.51 <0.0001 0.987 −0.55 <0.0001 0.995 
rs5943559 IL1RAPL1 −0.45 0.007 0.955 −0.56 <0.0001 0.995 
rs12387961 IL1RAPL1 0.37 0.261 0.832 0.46 0.009 0.928 
rs721953 IL1RAPL2 0.46 0.004 0.967 0.44 0.017 0.918 
rs1384360 IL1RAPL2 −0.45 0.009 0.952 −0.44 0.018 0.908 
rs6621992 IL1RAPL2 −0.45 0.010 0.955 −0.46 0.008 0.940 
rs7583215 IL1RL2 −0.55 <0.0001 0.996 −0.54 <0.0001 0.991 
rs2287041 IL1RL2 0.51 <0.0001 0.985 0.47 0.004 0.945 
rs3771188 IL1RL2 −0.54 <0.0001 0.993 −0.52 <0.0001 0.976 
rs315931 IL1RN −0.41 0.040 0.916 −0.46 0.007 0.941 
rs2637988 IL1RN −0.44 0.011 0.953 −0.47 0.004 0.954 
rs2029582 IL1RN −0.30 2.565 0.728 −0.46 0.008 0.936 
rs3087266 IL1RN −0.34 0.728 0.780 −0.46 0.008 0.928 
rs2386841 IL2RA 0.48 0.002 0.970 0.47 0.004 0.942 
rs11256497 IL2RA −0.49 0.002 0.973 −0.49 0.002 0.953 
rs2284034 IL2RB 0.37 0.244 0.834 0.48 0.003 0.950 
rs1003694 IL2RB 0.32 1.570 0.734 0.46 0.006 0.936 
rs228966 IL2RB −0.32 1.705 0.757 −0.48 0.003 0.963 
rs2284033 IL2RB 0.37 0.245 0.853 0.56 <0.0001 0.996 
rs228973 IL2RB 0.44 0.012 0.943 0.52 <0.0001 0.980 
rs228975 IL2RB −0.49 0.001 0.980 −0.59 <0.0001 0.999 
rs2235330 IL2RB 0.41 0.059 0.889 0.54 <0.0001 0.987 
rs2243268 IL4 −0.51 <0.0001 0.987 −0.58 <0.0001 0.997 
rs2243288 IL4 −0.43 0.021 0.932 −0.47 0.004 0.948 
rs2243290 IL4 0.49 0.001 0.978 0.54 <0.0001 0.991 
rs2070874 IL4 −0.50 0.001 0.984 −0.55 <0.0001 0.993 
rs3024672 IL4R −0.40 0.189 0.866 −0.53 0.001 0.975 
rs3024607 IL4R −0.48 0.006 0.974 −0.53 0.001 0.987 
rs17026370 IL5RA 0.47 0.011 0.951 0.55 <0.0001 0.990 
rs2066992 IL6 −0.41 0.049 0.899 −0.46 0.006 0.933 
rs2069835 IL6 −0.46 0.021 0.949 −0.53 0.002 0.982 
rs17505589 IL7 0.50 0.006 0.986 0.43 0.115 0.851 
rs11567697 IL7R 0.43 0.086 0.904 0.51 0.005 0.972 
rs1554286 IL10 −0.45 0.006 0.956 −0.56 <0.0001 0.994 
rs3024490 IL10 −0.39 0.103 0.880 −0.52 <0.0001 0.988 
rs2512144 IL10RA −0.38 0.343 0.832 −0.47 0.009 0.938 
rs999261 IL10RB 0.39 0.140 0.854 0.49 0.002 0.958 
rs2243115 IL12A −0.46 0.008 0.952 −0.43 0.045 0.843 
rs17129789 IL12RB2 −0.43 0.026 0.910 −0.51 0.001 0.971 
rs10521698 IL13RA2 −0.40 0.164 0.860 −0.50 0.003 0.956 
rs1589241 IL15 0.48 0.005 0.970 0.48 0.006 0.950 
rs2322262 IL15 0.47 0.008 0.962 0.49 0.005 0.953 
rs13106911 IL15 −0.36 0.361 0.811 −0.46 0.007 0.925 
rs8177636 IL15RA 0.39 0.179 0.858 0.47 0.006 0.942 
rs8177685 IL15RA −0.41 0.057 0.881 −0.47 0.004 0.931 
rs3136614 IL15RA −0.47 0.005 0.957 −0.40 0.125 0.798 
rs2296139 IL15RA 0.44 0.011 0.933 0.53 <0.0001 0.985 
rs12437819 IL16 −0.50 0.001 0.981 −0.41 0.071 0.846 
rs12438640 IL16 0.50 0.001 0.982 0.41 0.060 0.854 
rs10484879 IL17A −0.49 0.008 0.970 −0.39 0.425 0.770 
rs6518661 IL17RA −0.45 0.009 0.944 −0.43 0.026 0.896 
rs879576 IL17RA 0.45 0.025 0.931 0.50 0.004 0.953 
rs999514 IL17RB 0.47 0.004 0.964 0.45 0.015 0.916 
rs708567 IL17RC −0.40 0.066 0.890 −0.51 0.001 0.976 
rs6445854 IL17RD −0.43 0.030 0.912 −0.52 <0.0001 0.982 
rs4535195 IL17RD −0.44 0.013 0.942 −0.48 0.003 0.957 
rs12487790 IL17RD 0.43 0.018 0.935 0.52 <0.0001 0.983 
rs17216900 IL17RD 0.45 0.009 0.946 0.36 0.368 0.779 
rs12496746 IL17RD −0.46 0.006 0.951 −0.42 0.048 0.866 
rs455863 IL17RE −0.46 0.005 0.957 −0.57 <0.0001 0.996 
rs279581 IL17RE 0.39 0.116 0.878 0.50 0.001 0.974 
rs279572 IL17RE 0.37 0.208 0.854 0.48 0.002 0.960 
rs172155 IL17RE −0.37 0.244 0.847 −0.48 0.003 0.953 
rs2272128 IL18RAP −0.47 0.004 0.965 -0.39 0.125 0.829 
rs2243193 IL19 0.42 0.031 0.919 0.50 0.001 0.973 
rs12044804 IL19 −0.48 0.002 0.973 −0.62 <0.0001 1.000 
rs4845143 IL19 0.41 0.042 0.910 0.49 0.001 0.969 
rs12409415 IL19 −0.45 0.012 0.928 −0.49 0.002 0.945 
rs12046559 IL19 0.43 0.021 0.923 0.54 <0.0001 0.989 
rs12145973 IL19 0.59 <0.0001 1.000 0.42 0.106 0.820 
rs2138992 IL19 0.46 0.006 0.959 0.52 <0.0001 0.984 
rs2232360 IL20 −0.38 0.166 0.858 −0.46 0.007 0.934 
rs1322393 IL20RA 0.39 0.098 0.876 0.49 0.002 0.963 
rs1322394 IL20RA −0.38 0.206 0.844 −0.48 0.003 0.948 
rs75977 IL20RB -0.43 0.019 0.934 −0.47 0.005 0.940 
rs835634 IL20RB 0.43 0.020 0.932 0.46 0.008 0.929 
rs747842 IL20RB 0.43 0.023 0.929 0.46 0.008 0.930 
rs12934152 IL21R −0.57 <0.0001 0.999 −0.50 0.005 0.952 
rs10903022 IL22RA1 −0.42 0.037 0.920 −0.49 0.002 0.971 
rs10751768 IL22RA1 0.42 0.030 0.926 0.50 0.001 0.974 
rs3795302 IL22RA1 0.39 0.087 0.898 0.49 0.001 0.971 
rs4486393 IL22RA1 0.39 0.146 0.863 0.50 0.002 0.968 
rs4292900 IL22RA1 0.40 0.109 0.882 0.47 0.005 0.947 
rs16829209 IL22RA1 0.39 0.156 0.856 0.50 0.002 0.959 
rs11570915 IL26 0.40 0.132 0.852 0.53 0.001 0.980 
rs3814240 IL26 0.42 0.026 0.929 0.49 0.002 0.964 
rs3814241 IL26 0.50 0.001 0.982 0.47 0.004 0.946 
rs10878789 IL26 0.47 0.004 0.962 0.41 0.052 0.868 
rs9632389 IL31RA −0.48 0.005 0.960 −0.43 0.058 0.837 
rs10055201 IL31RA 0.39 0.120 0.869 0.45 0.009 0.927 
rs1554999 IL32 −0.48 0.002 0.965 −0.55 <0.0001 0.988 
a

Bonferroni-corrected p-value.

b

Percentile rank relative to the distribution of SNP control sets matched for allele frequency.

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