Table I.

Virus receptors used in this study

Virus Family Receptors Reference 
Old World arenaviruses Arenaviridae α-Dystroglycan Cao et al., 1998  
New World arenaviruses Arenaviridae Transferrin receptor Radoshitzky et al., 2007  
Norovirus Caliciviridae HBGA Huang et al., 2003; Lindesmith et al., 2003  
Japanese encephalitis virus Flaviviridae Hsp70 Das et al., 2009  
Influenza A Orthomyxoviridae Sialic acid Matlin et al., 1981  
Henipahvirus Paramyxoviridae Nephrin B2 Negrete et al., 2005  
Bunyavirus Phleboviridae DC-SIGN Kaplan et al., 1996  
Hepatitis A virus Picornaviridae TIM-1 Lozach et al., 2011b  
Poliovirus Picornaviridae CD155 Mendelsohn et al., 1989  
Rhinovirus (major group) Picornaviridae ICAM-1 Greve et al., 1989; Staunton et al., 1989  
Rhinovirus (minor group) Picornaviridae LDLR Hofer et al., 1994  
John Cunningham polyomavirus Polyomaviridae LSTc Neu et al., 2010  
SV40 polyomavirus Polyomaviridae GM1 Tsai et al., 2003  
Reovirus Reoviridae JAM Barton et al., 2001  
Sindbis virus Togaviridae Laminin receptor Wang et al., 1992  
SARS coronavirus Coronaviridae ACE 2 or L-SIGN Li et al., 2003; Jeffers et al., 2004  
Herpes simplex virus 1/2 Herpesviridae Nectin-1/2 or HVEM Montgomery et al., 1996; Geraghty et al., 1998; Krummenacher et al., 1998  
Measles virus Paramyxoviridae SLAM or Nectin-4 Tatsuo et al., 2000; Noyce et al., 2011  
Enterovirus 71 Picornaviridae PSGL-1 or SR-B2 Nishimura et al., 2009; Yamayoshi et al., 2009  
Human T cell leukemia virus 1 Retroviridae GLUT-1 or Neuropilin-1 Manel et al., 2003; Ghez et al., 2006  
Adenovirus 2 Adenoviridae CAR and αv integrins Wickham et al., 1993; Bergelson et al., 1997; Tomko et al., 1997  
Ebola virus Filoviridae TIM-1 and NPC1 Carette et al., 2011; Côté et al., 2011; Kondratowicz et al., 2011  
HCV Flaviviridae CD81 and SR-B1(claudin-1 and occludin) Pileri et al., 1998; Scarselli et al., 2002; Evans et al., 2007; Ploss et al., 2009  
Epstein–Barr virus Herpesviridae CD21 and MHC-II Fingeroth et al., 1984; Li et al., 1997  
Coxsackievirus B Picornaviridae DAF and CAR (occludin) Bergelson et al., 1997; Martino et al., 1998; Coyne et al., 2007  
Rotavirus Reoviridae Sialic acid and integrins Yolken et al., 1987; Coulson et al., 1997; Guerrero et al., 2000  
HIV Retroviridae CD4 and CCR5 or CXCR4 Dalgleish et al., 1984; Klatzman et al., 1984; Choe et al., 1996; Deng et al., 1996; Dragic et al., 1996; Feng et al., 1996  
Virus Family Receptors Reference 
Old World arenaviruses Arenaviridae α-Dystroglycan Cao et al., 1998  
New World arenaviruses Arenaviridae Transferrin receptor Radoshitzky et al., 2007  
Norovirus Caliciviridae HBGA Huang et al., 2003; Lindesmith et al., 2003  
Japanese encephalitis virus Flaviviridae Hsp70 Das et al., 2009  
Influenza A Orthomyxoviridae Sialic acid Matlin et al., 1981  
Henipahvirus Paramyxoviridae Nephrin B2 Negrete et al., 2005  
Bunyavirus Phleboviridae DC-SIGN Kaplan et al., 1996  
Hepatitis A virus Picornaviridae TIM-1 Lozach et al., 2011b  
Poliovirus Picornaviridae CD155 Mendelsohn et al., 1989  
Rhinovirus (major group) Picornaviridae ICAM-1 Greve et al., 1989; Staunton et al., 1989  
Rhinovirus (minor group) Picornaviridae LDLR Hofer et al., 1994  
John Cunningham polyomavirus Polyomaviridae LSTc Neu et al., 2010  
SV40 polyomavirus Polyomaviridae GM1 Tsai et al., 2003  
Reovirus Reoviridae JAM Barton et al., 2001  
Sindbis virus Togaviridae Laminin receptor Wang et al., 1992  
SARS coronavirus Coronaviridae ACE 2 or L-SIGN Li et al., 2003; Jeffers et al., 2004  
Herpes simplex virus 1/2 Herpesviridae Nectin-1/2 or HVEM Montgomery et al., 1996; Geraghty et al., 1998; Krummenacher et al., 1998  
Measles virus Paramyxoviridae SLAM or Nectin-4 Tatsuo et al., 2000; Noyce et al., 2011  
Enterovirus 71 Picornaviridae PSGL-1 or SR-B2 Nishimura et al., 2009; Yamayoshi et al., 2009  
Human T cell leukemia virus 1 Retroviridae GLUT-1 or Neuropilin-1 Manel et al., 2003; Ghez et al., 2006  
Adenovirus 2 Adenoviridae CAR and αv integrins Wickham et al., 1993; Bergelson et al., 1997; Tomko et al., 1997  
Ebola virus Filoviridae TIM-1 and NPC1 Carette et al., 2011; Côté et al., 2011; Kondratowicz et al., 2011  
HCV Flaviviridae CD81 and SR-B1(claudin-1 and occludin) Pileri et al., 1998; Scarselli et al., 2002; Evans et al., 2007; Ploss et al., 2009  
Epstein–Barr virus Herpesviridae CD21 and MHC-II Fingeroth et al., 1984; Li et al., 1997  
Coxsackievirus B Picornaviridae DAF and CAR (occludin) Bergelson et al., 1997; Martino et al., 1998; Coyne et al., 2007  
Rotavirus Reoviridae Sialic acid and integrins Yolken et al., 1987; Coulson et al., 1997; Guerrero et al., 2000  
HIV Retroviridae CD4 and CCR5 or CXCR4 Dalgleish et al., 1984; Klatzman et al., 1984; Choe et al., 1996; Deng et al., 1996; Dragic et al., 1996; Feng et al., 1996  

Virus particles engage a variety of cell surface molecules to facilitate entry. Some virus particles use single-receptor species; others use alternative molecules, either of which is sufficient, whereas other viruses require a specific combination of receptors. Factors in parentheses may not directly interact with virus particles; however, they are necessary for virus entry. Examples from each category are given and illustrate the diversity of receptors. The majority of the viruses listed are human pathogens. ACE, angiotensin-converting enzyme; DAF, decay-accelerating factor; HBGA, histoblood group antigen; HVEM, herpesvirus entry mediator; JAM, junctional adhesion molecule; PSGL-1, P-selectin glycoprotein ligand-1; SLAM, signaling lymphocyte-activation molecule.

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