Physiological and echocardiographic parameters in sham-operated and 1K1C mice lacking Notch1 in the heart
| . | WT . | . | cNotch1 KOs . | . | ||
|---|---|---|---|---|---|---|
. | Sham (n = 4–6) . | 1K1C (n = 5–6) . | Sham (n = 4–6) . | 1K1C (n = 5–8) . | ||
| Heart weight (mg) | 96.3 ± 3.6 | 156.2 ± 11.2 ** | 97.3 ± 3.6 | 144.2 ± 1.3 ** | ||
| Body weight (g) | 26.0 ± 0.6 | 27.2 ± 0.7 | 25.7 ± 0.7 | 26.2 ± 0.8 | ||
| Heart weight/body weight ratio (mg/g) | 3.7 ± 0.1 | 5.8 ± 0.5 ** | 3.8 ± 0.1 | 5.5 ± 0.5 ** | ||
| Blood pressure (mm Hg) | 117.1 ± 4.3 | 149.0 ± 3.2 ** | 120.3 ± 2.3 | 148.0 ± 3.2 ** | ||
| Heart rate (bpm) | 556 ± 90 | 528 ± 51 | 640 ± 20 | 561 ± 75 | ||
| Left ventricular wall thickness (mm) | ||||||
| diastole | 1.32 ± 0.04 | 1.89 ± 0.04 ** | 1.39 ± 0.04 | 2.11 ± 0.04 **†† | ||
| systole | 1.75 ± 0.09 | 2.23 ± 0.07 ** | 1.69 ± 0.03 | 2.43 ± 0.05 **† | ||
| Left ventricular diameter (mm) | ||||||
| diastole | 3.18 ± 0.19 | 3.17 ± 0.12 | 2.97 ± 0.07 | 3.17 ± 0.08 | ||
| systole | 1.75 ± 0.06 | 1.60 ± 0.08 | 1.71 ± 0.07 | 2.01 ± 0.07 **†† | ||
| Septum thickness (mm) | ||||||
| diastole | 0.38 ± 0.04 | 0.39 ± 0.09 | 0.34 ± 0.02 | 0.49 ± 0.04 ** | ||
| systole | 0.48 ± 0.04 | 0.60 ± 0.13 | 0.46 ± 0.02 | 0.61 ± 0.05 ** | ||
| Fraction of shortening (%) | 44.8 ± 1.0 | 49.5 ± 1.5 * | 42.4 ± 0.8 | 36.4 ± 0.8 **†† | ||
| . | WT . | . | cNotch1 KOs . | . | ||
|---|---|---|---|---|---|---|
. | Sham (n = 4–6) . | 1K1C (n = 5–6) . | Sham (n = 4–6) . | 1K1C (n = 5–8) . | ||
| Heart weight (mg) | 96.3 ± 3.6 | 156.2 ± 11.2 ** | 97.3 ± 3.6 | 144.2 ± 1.3 ** | ||
| Body weight (g) | 26.0 ± 0.6 | 27.2 ± 0.7 | 25.7 ± 0.7 | 26.2 ± 0.8 | ||
| Heart weight/body weight ratio (mg/g) | 3.7 ± 0.1 | 5.8 ± 0.5 ** | 3.8 ± 0.1 | 5.5 ± 0.5 ** | ||
| Blood pressure (mm Hg) | 117.1 ± 4.3 | 149.0 ± 3.2 ** | 120.3 ± 2.3 | 148.0 ± 3.2 ** | ||
| Heart rate (bpm) | 556 ± 90 | 528 ± 51 | 640 ± 20 | 561 ± 75 | ||
| Left ventricular wall thickness (mm) | ||||||
| diastole | 1.32 ± 0.04 | 1.89 ± 0.04 ** | 1.39 ± 0.04 | 2.11 ± 0.04 **†† | ||
| systole | 1.75 ± 0.09 | 2.23 ± 0.07 ** | 1.69 ± 0.03 | 2.43 ± 0.05 **† | ||
| Left ventricular diameter (mm) | ||||||
| diastole | 3.18 ± 0.19 | 3.17 ± 0.12 | 2.97 ± 0.07 | 3.17 ± 0.08 | ||
| systole | 1.75 ± 0.06 | 1.60 ± 0.08 | 1.71 ± 0.07 | 2.01 ± 0.07 **†† | ||
| Septum thickness (mm) | ||||||
| diastole | 0.38 ± 0.04 | 0.39 ± 0.09 | 0.34 ± 0.02 | 0.49 ± 0.04 ** | ||
| systole | 0.48 ± 0.04 | 0.60 ± 0.13 | 0.46 ± 0.02 | 0.61 ± 0.05 ** | ||
| Fraction of shortening (%) | 44.8 ± 1.0 | 49.5 ± 1.5 * | 42.4 ± 0.8 | 36.4 ± 0.8 **†† | ||
Statistical significance: *, P < 0.05 and **, P < 0.01 as compared to corresponding vehicle-treated groups; †, P < 0.05 and ††, P < 0.01 as compared to corresponding WT groups.