Physiological and echocardiographic parameters in mice treated with the γ-secretase inhibitor LY411,575
| . | WT . | . | TG1306/1R . | . | ||
|---|---|---|---|---|---|---|
. | Vehicle (n = 5–6) . | Inhibitor (n = 6) . | Vehicle (n = 6) . | Inhibitor (n = 6) . | ||
| Heart weight (mg) | 122.8 ± 7.1 | 125.5 ± 11.1 | 141.3 ± 7.8 | 183.7 ± 14.3** | ||
| Body weight (g) | 24.9 ± 1.0 | 25.0 ± 0.4 | 26.8 ± 0.9 | 26.1 ± 1.1 | ||
| Heart weight/body weight ratio (mg/g) | 4.9 ± 0.2 | 5.0 ± 0.5 | 5.3 ± 0.2 | 7.1 ± 0.7** | ||
| Blood pressure (mm Hg) | 114.4 ± 2.7 | 111.0 ± 5.2 | 114.7 ± 3.6 | 113.6 ± 3.8 | ||
| Heart rate (bpm) | 611 ± 14 | 609 ± 6 | 617 ± 6 | 606 ± 16 | ||
| Left ventricular wall thickness (mm) | ||||||
| diastole | 1.57 ± 0.04 | 1.59 ± 0.10 | 1.66 ± 0.09 | 2.14 ± 0.13*†† | ||
| systole | 1.99 ± 0.03 | 1.90 ± 0.12 | 1.98 ± 0.10 | 2.39 ± 0.13**†† | ||
| Left ventricular diameter (mm) | ||||||
| diastole | 3.03 ± 0.04 | 2.87 ± 0.15 | 3.12 ± 0.15 | 3.23 ± 0.13*†† | ||
| systole | 1.73 ± 0.06 | 1.55 ± 0.06 | 1.71 ± 0.14 | 1.59 ± 0.06 | ||
| Septum thickness (mm) | ||||||
| diastole | 0.33 ± 0.02 | 0.38 ± 0.02 | 0.33 ± 0.03 | 0.34 ± 0.03 | ||
| systole | 0.46 ± 0.02 | 0.48 ± 0.01 | 0.39 ± 0.05 | 0.51 ± 0.06 | ||
| Fraction of shortening (%) | 43.1 ± 1.6 | 45.8 ± 1.0 | 45.7 ± 2.2 | 50.7 ± 1.2**†† | ||
| . | WT . | . | TG1306/1R . | . | ||
|---|---|---|---|---|---|---|
. | Vehicle (n = 5–6) . | Inhibitor (n = 6) . | Vehicle (n = 6) . | Inhibitor (n = 6) . | ||
| Heart weight (mg) | 122.8 ± 7.1 | 125.5 ± 11.1 | 141.3 ± 7.8 | 183.7 ± 14.3** | ||
| Body weight (g) | 24.9 ± 1.0 | 25.0 ± 0.4 | 26.8 ± 0.9 | 26.1 ± 1.1 | ||
| Heart weight/body weight ratio (mg/g) | 4.9 ± 0.2 | 5.0 ± 0.5 | 5.3 ± 0.2 | 7.1 ± 0.7** | ||
| Blood pressure (mm Hg) | 114.4 ± 2.7 | 111.0 ± 5.2 | 114.7 ± 3.6 | 113.6 ± 3.8 | ||
| Heart rate (bpm) | 611 ± 14 | 609 ± 6 | 617 ± 6 | 606 ± 16 | ||
| Left ventricular wall thickness (mm) | ||||||
| diastole | 1.57 ± 0.04 | 1.59 ± 0.10 | 1.66 ± 0.09 | 2.14 ± 0.13*†† | ||
| systole | 1.99 ± 0.03 | 1.90 ± 0.12 | 1.98 ± 0.10 | 2.39 ± 0.13**†† | ||
| Left ventricular diameter (mm) | ||||||
| diastole | 3.03 ± 0.04 | 2.87 ± 0.15 | 3.12 ± 0.15 | 3.23 ± 0.13*†† | ||
| systole | 1.73 ± 0.06 | 1.55 ± 0.06 | 1.71 ± 0.14 | 1.59 ± 0.06 | ||
| Septum thickness (mm) | ||||||
| diastole | 0.33 ± 0.02 | 0.38 ± 0.02 | 0.33 ± 0.03 | 0.34 ± 0.03 | ||
| systole | 0.46 ± 0.02 | 0.48 ± 0.01 | 0.39 ± 0.05 | 0.51 ± 0.06 | ||
| Fraction of shortening (%) | 43.1 ± 1.6 | 45.8 ± 1.0 | 45.7 ± 2.2 | 50.7 ± 1.2**†† | ||
Statistical significance: *, P < 0.05 and **, P < 0.01 as compared to corresponding vehicle-treated groups; †, P < 0.05 and ††, P < 0.01 as compared to corresponding WT groups.