Table I. Functional diversity of SUN and... | Rockefeller University Press

Table I.

Functional diversity of SUN and KASH domain proteins

	Localization/interaction
		Perinuclear space		Cytoplasm
Organism	Nucleoplasm	SUN	KASH	Motor	Cytoskeleton	Function	References
C. elegans	Ce-lamin	UNC-84	UNC-83	Kinesin1	MT	Nuclear migration	Starr et al., 2001; Meyerzon et al., 2009
C. elegans	Ce-lamin	UNC-84	ANC-1	NA	Actin	Nuclear anchorage	Malone et al., 1999; Starr and Han, 2002
C. elegans	Ce-lamin	SUN-1/MTF-1	ZYG-12	Dynein	Centrosome	Centrosome tethering at NE	Malone et al., 2003
C. elegans	Ce-lamin	SUN-1/MTF-1	ZYG-12	Unknown	Unknown	Meiotic chromosome dynamics	Penkner et al., 2007
D. melanogaster	LamDm0	Klaroid	Klarsicht	Dynein	MT	Nuclear migration	Mosley-Bishop et al., 1999; Kracklauer et al., 2007
H. sapiens	Lamin A/C-B1	Sun1/2	Syne-1/2	NA	Actin	Nuclear anchorage	Grady et al., 2005; Zhang et al., 2007b; Méjat et al., 2009; Lei et al., 2009
H. sapiens	Lamin A/C-B1	Sun1/2	Nesprin-3	NA	Plectin	Nuclear coupling to IF	Wilhelmsen et al., 2005
H. sapiens	Lamin A/C-B1	Sun1/2	Nesprin-4	Kinesin1	MT	Nuclear migration	Roux et al., 2009
S. pombe	Bqt1/2	Sad1	Kms1/2	Dynein	MT	Meiotic chromosome dynamics	Chikashige et al., 2006; Miki et al., 2004
S. pombe	Ima1, Ndc80	Sad1	Kms2	Unknown	MT	Centromere-SPB coupling	King et al., 2008
S. cerevisiae	Ndj1	Mps3	Unknown	Unknown	Unknown	Meiotic chromosome dynamics	Conrad et al., 2008
S. cerevisiae	Sir4	Mps3	Unknown	Unknown	Unknown	Mitotic telomere tethering at NE	Bupp et al., 2007
S. cerevisiae	Unknown	Mps3	(Mps2)	Unknown	SPB	SPB tethering at NE	Jaspersen et al., 2006

	Localization/interaction
		Perinuclear space		Cytoplasm
Organism	Nucleoplasm	SUN	KASH	Motor	Cytoskeleton	Function	References
C. elegans	Ce-lamin	UNC-84	UNC-83	Kinesin1	MT	Nuclear migration	Starr et al., 2001; Meyerzon et al., 2009
C. elegans	Ce-lamin	UNC-84	ANC-1	NA	Actin	Nuclear anchorage	Malone et al., 1999; Starr and Han, 2002
C. elegans	Ce-lamin	SUN-1/MTF-1	ZYG-12	Dynein	Centrosome	Centrosome tethering at NE	Malone et al., 2003
C. elegans	Ce-lamin	SUN-1/MTF-1	ZYG-12	Unknown	Unknown	Meiotic chromosome dynamics	Penkner et al., 2007
D. melanogaster	LamDm0	Klaroid	Klarsicht	Dynein	MT	Nuclear migration	Mosley-Bishop et al., 1999; Kracklauer et al., 2007
H. sapiens	Lamin A/C-B1	Sun1/2	Syne-1/2	NA	Actin	Nuclear anchorage	Grady et al., 2005; Zhang et al., 2007b; Méjat et al., 2009; Lei et al., 2009
H. sapiens	Lamin A/C-B1	Sun1/2	Nesprin-3	NA	Plectin	Nuclear coupling to IF	Wilhelmsen et al., 2005
H. sapiens	Lamin A/C-B1	Sun1/2	Nesprin-4	Kinesin1	MT	Nuclear migration	Roux et al., 2009
S. pombe	Bqt1/2	Sad1	Kms1/2	Dynein	MT	Meiotic chromosome dynamics	Chikashige et al., 2006; Miki et al., 2004
S. pombe	Ima1, Ndc80	Sad1	Kms2	Unknown	MT	Centromere-SPB coupling	King et al., 2008
S. cerevisiae	Ndj1	Mps3	Unknown	Unknown	Unknown	Meiotic chromosome dynamics	Conrad et al., 2008
S. cerevisiae	Sir4	Mps3	Unknown	Unknown	Unknown	Mitotic telomere tethering at NE	Bupp et al., 2007
S. cerevisiae	Unknown	Mps3	(Mps2)	Unknown	SPB	SPB tethering at NE	Jaspersen et al., 2006

The various physiological functions of protein networks based on SUN/KASH interactions across the NE are listed horizontally. The localization (nucleoplasm, perinuclear space, or cytoplasm) of each network components as well as the nomenclature of SUN and KASH proteins among different species are indicated. Mps2 is in parentheses because it does not contain any detectable KASH domain even though it is involved with Mps3 in SPB tethering at the NE in S. cerevisiae. MT, microtubule; NA, not applicable.

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