Connections between the DNA damage response and ubiquitin
| Substrate | PIKK | Ubiquitin linkage | E3 ligase | E2 ligase | DUB | Function |
| FancD2 | ATR | Mono | FancL | Unknown | USP1 | DSB localization |
| FancI | ATM/ATR | Mono | FancL | Ube2T | USP1 | DSB localization |
| BRCA1 | ATM/ATR | K6 (in vitro) | BRCA1-BARD1 | Ubch5c | Unknown | Unknown |
| CtIP | ATM | Unknown | BRCA1-BARD1 | Ubch5c | Unknown | DSB localization |
| H2A, H2AX | ATM/ATR/DNA-PK | Mono, K63 | RNF8, RNF168 | Ubc13 | USP3, BRCC36 | Recruitment of factors to DSB |
| Substrate | PIKK | Ubiquitin linkage | E3 ligase | E2 ligase | DUB | Function |
| FancD2 | ATR | Mono | FancL | Unknown | USP1 | DSB localization |
| FancI | ATM/ATR | Mono | FancL | Ube2T | USP1 | DSB localization |
| BRCA1 | ATM/ATR | K6 (in vitro) | BRCA1-BARD1 | Ubch5c | Unknown | Unknown |
| CtIP | ATM | Unknown | BRCA1-BARD1 | Ubch5c | Unknown | DSB localization |
| H2A, H2AX | ATM/ATR/DNA-PK | Mono, K63 | RNF8, RNF168 | Ubc13 | USP3, BRCC36 | Recruitment of factors to DSB |
DNA-PK, DNA-dependent protein kinase.