Table I.

Connections between the DNA damage response and ubiquitin

Substrate PIKK Ubiquitin linkage E3 ligase E2 ligase DUB Function 
FancD2 ATR Mono FancL Unknown USP1 DSB localization 
FancI ATM/ATR Mono FancL Ube2T USP1 DSB localization 
BRCA1 ATM/ATR K6 (in vitro) BRCA1-BARD1 Ubch5c Unknown Unknown 
CtIP ATM Unknown BRCA1-BARD1 Ubch5c Unknown DSB localization 
H2A, H2AX ATM/ATR/DNA-PK Mono, K63 RNF8, RNF168 Ubc13 USP3, BRCC36 Recruitment of factors to DSB 

DNA-PK, DNA-dependent protein kinase.

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