Table I.

Expression of inhibitory and trafficking receptors on B cell subpopulations of HIV-viremic individuals

1
2
3
P values
Receptor
Classical memorya
Tissuelike memory
Naive
1 vs. 2
1 vs. 3
2 vs. 3
Inhibitory       
    FCRL4 12 (7.7–26)b 25 (16–40) 3.8 (1.5–9.7) 0.002 0.0005 0.0005 
    CD85j 23 (14–40) 49 (24–85) 12 (4.4–26) 0.002 0.002 0.002 
    CD22 197 (81–388) 593 (258–997) 442 (258–655) 0.0005 0.0005 0.028 
    CD85k 3.2 (0.8–11) 3.4 (0.3–12) 1.1 (0.2–4.1) 0.25 0.002 0.002 
    CD72 20 (7.7–29) 62 (20–85) 57 (32–72) 0.002 0.002 0.270 
    LAIR–1 23 (12–42) 66 (21–162) 159 (84–250) 0.0005 0.0005 0.002 
Trafficking       
    CXCR3 73 (19–153) 222 (55–384) 86 (23–207) 0.0005 0.136 0.0005 
    CD11c 64 (38–228) 190 (71–365) 38 (8.7–185) 0.0005 0.001 0.0005 
    CCR6 26 (11–49) 54 (24–165) 33 (15–101) 0.0005 0.003 0.003 
    CCR7 9.3 (3.0–30) 4.4 (1.4–12) 9.8 (2.5–30) 0.0005 0.207 0.001 
    CD62L 114 (32–325) 13 (7.1–66) 70 (25–370) 0.002 0.176 0.0005 
    CXCR5 70 (16–147) 40 (8.7–126) 177 (96–281) 0.021 0.0005 0.002 
    CXCR4 8.2 (2.9–14) 7.5 (2.9–18) 29 (8.7–49) 0.478 0.0005 0.002 
1
2
3
P values
Receptor
Classical memorya
Tissuelike memory
Naive
1 vs. 2
1 vs. 3
2 vs. 3
Inhibitory       
    FCRL4 12 (7.7–26)b 25 (16–40) 3.8 (1.5–9.7) 0.002 0.0005 0.0005 
    CD85j 23 (14–40) 49 (24–85) 12 (4.4–26) 0.002 0.002 0.002 
    CD22 197 (81–388) 593 (258–997) 442 (258–655) 0.0005 0.0005 0.028 
    CD85k 3.2 (0.8–11) 3.4 (0.3–12) 1.1 (0.2–4.1) 0.25 0.002 0.002 
    CD72 20 (7.7–29) 62 (20–85) 57 (32–72) 0.002 0.002 0.270 
    LAIR–1 23 (12–42) 66 (21–162) 159 (84–250) 0.0005 0.0005 0.002 
Trafficking       
    CXCR3 73 (19–153) 222 (55–384) 86 (23–207) 0.0005 0.136 0.0005 
    CD11c 64 (38–228) 190 (71–365) 38 (8.7–185) 0.0005 0.001 0.0005 
    CCR6 26 (11–49) 54 (24–165) 33 (15–101) 0.0005 0.003 0.003 
    CCR7 9.3 (3.0–30) 4.4 (1.4–12) 9.8 (2.5–30) 0.0005 0.207 0.001 
    CD62L 114 (32–325) 13 (7.1–66) 70 (25–370) 0.002 0.176 0.0005 
    CXCR5 70 (16–147) 40 (8.7–126) 177 (96–281) 0.021 0.0005 0.002 
    CXCR4 8.2 (2.9–14) 7.5 (2.9–18) 29 (8.7–49) 0.478 0.0005 0.002 
a

Refer to Fig. 1 C for gating used to identify each subpopulation.

b

Values are median and range of mean fluorescence intensities (n = 12) after subtraction of background staining with isotype control.

View Large
This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal