Table II. Transgenic mice that express... | Rockefeller University Press

Table II.

Transgenic mice that express the truncated apoL-I devoid of the SRA-interacting domain do not protect from infection with T. b. brucei or T. b. brucei-SRA

Transgenic DNA	Trypanosome species (1.78 × 10⁶ injected i.p.)	Number mice alive/ number mice infected
		Day 3	Day 50
ApoL-I	T. b. brucei	5/5	3/5^{^a}
Tr-apoL-I		0/5^{^b}
Vector		0/5^{^b}
ApoL-I	T. b. brucei SRA	0/5^{^b}
Tr-ApoL-I		0/5^{^b}
Vector		0/5^{^b}

Transgenic DNA	Trypanosome species (1.78 × 10⁶ injected i.p.)	Number mice alive/ number mice infected
		Day 3	Day 50
ApoL-I	T. b. brucei	5/5	3/5^{^a}
Tr-apoL-I		0/5^{^b}
Vector		0/5^{^b}
ApoL-I	T. b. brucei SRA	0/5^{^b}
Tr-ApoL-I		0/5^{^b}
Vector		0/5^{^b}

Tg mice expressing full-length apoL-I or truncated apoL-I infected with 1.78 x10⁶T. b. brucei (Lister 427-derived line) or T. b. brucei-SRA (Lister 427-derived line expressing the SRA gene). n = 5 per group.

No parasites detectable.

Parasitemia ≥ 1 × 10⁹/ml before mice were killed.

View Large

This Feature Is Available To Subscribers Only