Transgenic mice that express the apoL-I gene ameliorate infection with T. brucei, T. evansi, and T. congolense
| Transgenic DNA . | Trypanosome species (1.78 × 106 injected i.p.) . | Number mice alive/ number mice infected . | . | . | ||
|---|---|---|---|---|---|---|
| Day 3 | Day 20 | Day 50 | ||||
| ApoL-I | T. brucei | 5/5 | 3/5b | |||
| Vector | 0/5a | |||||
| ApoL-I | T. brucei SRA | 0/5a | ||||
| Vector | 0/5a | |||||
| ApoL-I | T. evansi | 5/5 | 4/5c | |||
| Vector | 5/5 | 1/5d | ||||
| ApoL-I | T. congolense | 5/5 | 3/5b | |||
| Vector | 2/5 | 2/5d | ||||
| Transgenic DNA . | Trypanosome species (1.78 × 106 injected i.p.) . | Number mice alive/ number mice infected . | . | . | ||
|---|---|---|---|---|---|---|
| Day 3 | Day 20 | Day 50 | ||||
| ApoL-I | T. brucei | 5/5 | 3/5b | |||
| Vector | 0/5a | |||||
| ApoL-I | T. brucei SRA | 0/5a | ||||
| Vector | 0/5a | |||||
| ApoL-I | T. evansi | 5/5 | 4/5c | |||
| Vector | 5/5 | 1/5d | ||||
| ApoL-I | T. congolense | 5/5 | 3/5b | |||
| Vector | 2/5 | 2/5d | ||||
Mice expressing the gene for apoL-I were infected with 1.78 × 106T. b. brucei (Lister 427-derived line), T. b. brucei-SRA (Lister 427-derived line expressing the SRA gene), T. evansi (AnTat 3), or T. congolense (STIB 68Q). n = 5 per group.
Parasitemia ≥ 1 × 109 before mice were killed.
No parasites detectable.
Died of unknown cause, did not have detectable parasites.
Parasitemia = 1 × 106/ ml.