Table I.

Paraspeckle proteins

Protein Synonyms Features Referencea 
Core paraspeckle proteins 
P54NRB NONO, NMT55, NRB54 DBHS; required for paraspeckle integrity in HeLa cells Fox et al., 2002  
PSF SFPQ DBHS; required for paraspeckle integrity in HeLa cells Prasanth et al., 2005  
PSPC1 PSP1 DBHS Fox et al., 2002  
Other paraspeckle proteins 
CoAAb PSP2, RBM14, SIP, SYTIP1 Transcriptional/splicing coregulator Fox et al., 2002  
CFIm68 CPSF6, HPBRII-4 RNA 3′ end cleavage factor; also found in nuclear speckles Dettwiler et al., 2004  
SOX9bc SRA1 Developmental transcription factor Hata et al., 2008  
WTXb NA Wilms tumor protein, tumor suppressor Rivera et al., 2009  
WT1(+KTS)b WAGR Wilms tumor transcription factor, partial colocalization with paraspeckles Dutton et al., 2006  
BCL11Abc CTIP1, ZNF856 Zinc finger transcription factor Liu et al., 2006  
RNA Pol II NA Also found associated with chromatin and nuclear speckles Xie et al., 2006  
Protein Synonyms Features Referencea 
Core paraspeckle proteins 
P54NRB NONO, NMT55, NRB54 DBHS; required for paraspeckle integrity in HeLa cells Fox et al., 2002  
PSF SFPQ DBHS; required for paraspeckle integrity in HeLa cells Prasanth et al., 2005  
PSPC1 PSP1 DBHS Fox et al., 2002  
Other paraspeckle proteins 
CoAAb PSP2, RBM14, SIP, SYTIP1 Transcriptional/splicing coregulator Fox et al., 2002  
CFIm68 CPSF6, HPBRII-4 RNA 3′ end cleavage factor; also found in nuclear speckles Dettwiler et al., 2004  
SOX9bc SRA1 Developmental transcription factor Hata et al., 2008  
WTXb NA Wilms tumor protein, tumor suppressor Rivera et al., 2009  
WT1(+KTS)b WAGR Wilms tumor transcription factor, partial colocalization with paraspeckles Dutton et al., 2006  
BCL11Abc CTIP1, ZNF856 Zinc finger transcription factor Liu et al., 2006  
RNA Pol II NA Also found associated with chromatin and nuclear speckles Xie et al., 2006  

NA, not applicable.

a

Localization to paraspeckles was first shown in these studies.

b

Only overexpressed proteins have been assessed for localization in paraspeckles.

c

Further studies need to address whether these proteins are genuine paraspeckle components or are retargeting DBHS proteins into different subnuclear locations.

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