Table II.

Static and dynamic trabecular bone parameters in long bones of control and unloaded WT (WT) and BSP−/− mice

Genotype
WT
BSP−/−
Treatment
Control
Unloaded
Control
Unloaded
Sex
Static parametersa      
SMI 2.3 ± 0.1 3.0 ± 0.1bc 1.7 ± 0.1d 2.0 ± 0.1e Male 
Tb.N (/mm) 3.6 ± 0.2 2.3 ± 0.2e 6.1 ± 0.3f 5.4 ± 0.3e  
Tb.Th (μm) 51 ± 1.8 46 ± 0.8e 53 ± 1.6 48 ± 1.1e  
Tb.Sp (μm) 30 ± 2.6 39 ± 3.2e 16 ± 0.8g 18 ± 1.1e  
n 9 12 6 6  
SMI 2.1 ± 0.1 2.4 ± 0.04e 2.2 ± 0.1 2.6 ± 0.1h Female 
Tb.N (/mm) 2.1 ± 0.1 2.4 ± 0.2 3.7 ± 0.3g 3.2 ± 0.3i  
Tb.Th (μm) 67 ± 1.4 53 ± 2.0i 47±1.6f 46 ± 2.1  
Tb.Sp (μm) 50 ± 3.0 44 ± 3.3 28 ± 2.5g 34 ± 4.2  
n 7 8 6 8  
Dynamic parametersj      
N.Oc/B.Ar (/μm2) 379 ± 50 383±42 346 ± 39 354 ± 65 Male 
MS/BS (%) 13.04 ± 2.69 6.14 ± 1.41e 4.93 ± 1.68k 1.18 ± 0.27h  
MAR (μm/day) 2.38 ± 0.36 1.31 ± 0.10h 1.49 ± 0.19k 1.55 ± 0.88  
n 9 9 7 9  
N.Oc/B.Ar (/μm2) 288 ± 50 384 ± 63 277 ± 38 386 ± 37 Female 
MS/BS (%) 21.51 ± 3.19 6.38 ± 1.53i 4.93 ± 1.34g 5.28 ± 1.12  
MAR (μm/day) 2.98 ± 0.18 1.18 ± 0.22i 1.11 ± 0.14g 1.17 ± 0.13  
n 9 10 7 7  

See Materials and methods for details.

a

μCT analysis on excised tibias.

b

P < 0.0001 versus loaded control.

c

Results are the mean ± the SEM.

d

P < 0.01 versus matched WT.

e

P < 0.05 versus loaded control.

f

P < 0.0001 versus matched WT.

g

P < 0.001 versus matched WT.

h

P < 0.01 versus loaded control.

i

P < 0.001 versus loaded control.

j

Histomorphometry on excised femurs.

k

P < 0.05 versus matched WT.

[ViewLarge]
This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal

Gift article access

As a benefit of your subscription, you can share temporary access to restricted articles.

Each link will stop working after 30 days or 10 uses. You may create up to 10 links in a 30 day period.

Please sign in to your personal account to gift article access.

Register

Gift article access

As a benefit of your subscription, you can share temporary access to restricted articles.

Each link will stop working after 30 days or 10 uses. You may create up to 10 links in a 30 day period.

Gift articles remaining: --

Gift article access

Each link will stop working after 30 days or 10 uses. You may create up to 10 links in a 30 day period.

Gift articles remaining: --

Gift article access

As a benefit of your subscription, you can share temporary access to restricted articles.

Each link will stop working after 30 days or 10 uses.

You have reached the limit of 10 links within a 30 day period.

Sharing Unavailable

Sharing content requires targeting cookies to be enabled. Please update your cookie preferences to use this feature.