Static and dynamic trabecular bone parameters in long bones of control and unloaded WT (WT) and BSP−/− mice
| Genotype . | WT . | . | BSP−/− . | . | . | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Treatment . | Control . | Unloaded . | Control . | Unloaded . | Sex . | |||||
| Static parametersa | ||||||||||
| SMI | 2.3 ± 0.1 | 3.0 ± 0.1bc | 1.7 ± 0.1d | 2.0 ± 0.1e | Male | |||||
| Tb.N (/mm) | 3.6 ± 0.2 | 2.3 ± 0.2e | 6.1 ± 0.3f | 5.4 ± 0.3e | ||||||
| Tb.Th (μm) | 51 ± 1.8 | 46 ± 0.8e | 53 ± 1.6 | 48 ± 1.1e | ||||||
| Tb.Sp (μm) | 30 ± 2.6 | 39 ± 3.2e | 16 ± 0.8g | 18 ± 1.1e | ||||||
| n | 9 | 12 | 6 | 6 | ||||||
| SMI | 2.1 ± 0.1 | 2.4 ± 0.04e | 2.2 ± 0.1 | 2.6 ± 0.1h | Female | |||||
| Tb.N (/mm) | 2.1 ± 0.1 | 2.4 ± 0.2 | 3.7 ± 0.3g | 3.2 ± 0.3i | ||||||
| Tb.Th (μm) | 67 ± 1.4 | 53 ± 2.0i | 47±1.6f | 46 ± 2.1 | ||||||
| Tb.Sp (μm) | 50 ± 3.0 | 44 ± 3.3 | 28 ± 2.5g | 34 ± 4.2 | ||||||
| n | 7 | 8 | 6 | 8 | ||||||
| Dynamic parametersj | ||||||||||
| N.Oc/B.Ar (/μm2) | 379 ± 50 | 383±42 | 346 ± 39 | 354 ± 65 | Male | |||||
| MS/BS (%) | 13.04 ± 2.69 | 6.14 ± 1.41e | 4.93 ± 1.68k | 1.18 ± 0.27h | ||||||
| MAR (μm/day) | 2.38 ± 0.36 | 1.31 ± 0.10h | 1.49 ± 0.19k | 1.55 ± 0.88 | ||||||
| n | 9 | 9 | 7 | 9 | ||||||
| N.Oc/B.Ar (/μm2) | 288 ± 50 | 384 ± 63 | 277 ± 38 | 386 ± 37 | Female | |||||
| MS/BS (%) | 21.51 ± 3.19 | 6.38 ± 1.53i | 4.93 ± 1.34g | 5.28 ± 1.12 | ||||||
| MAR (μm/day) | 2.98 ± 0.18 | 1.18 ± 0.22i | 1.11 ± 0.14g | 1.17 ± 0.13 | ||||||
| n | 9 | 10 | 7 | 7 | ||||||
| Genotype . | WT . | . | BSP−/− . | . | . | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Treatment . | Control . | Unloaded . | Control . | Unloaded . | Sex . | |||||
| Static parametersa | ||||||||||
| SMI | 2.3 ± 0.1 | 3.0 ± 0.1bc | 1.7 ± 0.1d | 2.0 ± 0.1e | Male | |||||
| Tb.N (/mm) | 3.6 ± 0.2 | 2.3 ± 0.2e | 6.1 ± 0.3f | 5.4 ± 0.3e | ||||||
| Tb.Th (μm) | 51 ± 1.8 | 46 ± 0.8e | 53 ± 1.6 | 48 ± 1.1e | ||||||
| Tb.Sp (μm) | 30 ± 2.6 | 39 ± 3.2e | 16 ± 0.8g | 18 ± 1.1e | ||||||
| n | 9 | 12 | 6 | 6 | ||||||
| SMI | 2.1 ± 0.1 | 2.4 ± 0.04e | 2.2 ± 0.1 | 2.6 ± 0.1h | Female | |||||
| Tb.N (/mm) | 2.1 ± 0.1 | 2.4 ± 0.2 | 3.7 ± 0.3g | 3.2 ± 0.3i | ||||||
| Tb.Th (μm) | 67 ± 1.4 | 53 ± 2.0i | 47±1.6f | 46 ± 2.1 | ||||||
| Tb.Sp (μm) | 50 ± 3.0 | 44 ± 3.3 | 28 ± 2.5g | 34 ± 4.2 | ||||||
| n | 7 | 8 | 6 | 8 | ||||||
| Dynamic parametersj | ||||||||||
| N.Oc/B.Ar (/μm2) | 379 ± 50 | 383±42 | 346 ± 39 | 354 ± 65 | Male | |||||
| MS/BS (%) | 13.04 ± 2.69 | 6.14 ± 1.41e | 4.93 ± 1.68k | 1.18 ± 0.27h | ||||||
| MAR (μm/day) | 2.38 ± 0.36 | 1.31 ± 0.10h | 1.49 ± 0.19k | 1.55 ± 0.88 | ||||||
| n | 9 | 9 | 7 | 9 | ||||||
| N.Oc/B.Ar (/μm2) | 288 ± 50 | 384 ± 63 | 277 ± 38 | 386 ± 37 | Female | |||||
| MS/BS (%) | 21.51 ± 3.19 | 6.38 ± 1.53i | 4.93 ± 1.34g | 5.28 ± 1.12 | ||||||
| MAR (μm/day) | 2.98 ± 0.18 | 1.18 ± 0.22i | 1.11 ± 0.14g | 1.17 ± 0.13 | ||||||
| n | 9 | 10 | 7 | 7 | ||||||
See Materials and methods for details.
μCT analysis on excised tibias.
P < 0.0001 versus loaded control.
Results are the mean ± the SEM.
P < 0.01 versus matched WT.
P < 0.05 versus loaded control.
P < 0.0001 versus matched WT.
P < 0.001 versus matched WT.
P < 0.01 versus loaded control.
P < 0.001 versus loaded control.
Histomorphometry on excised femurs.
P < 0.05 versus matched WT.