Table I.

Tissue mineralization of cortical bone, measured by μCT in femurs of WT and BSP−/− mice

Age
Sex
Genotype
mg HAP/cm3
% Difference with +/+a
E18 Fetus +/+ 269 ± 12.6  
  −/− 245 ± 10.4b −8.90% 
4 mo Male +/+ 1,331 ± 23.0c  
  −/− 1,266 ± 30.0de −4.90% 
 Female +/+ 1,378 ± 10.5  
  −/− 1,313 ± 17.8d −4.70% 
12 mo Male +/+ 1,468 ± 40.8f  
  −/− 1,465 ± 16.4f −0.20% 
 Female +/+ 1,344 ± 23.3  
  −/− 1,310 ± 9.2 −2.50% 
a

Significant differences with WT are shown in bold.

b

P < 0.01 versus matched WT.

c

P < 0.01 versus matched sex.

d

P < 0.001 versus matched WT.

e

P < 0.001 versus matched sex.

f

P < 0.05 versus matched sex.

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