Table III.

Genetic interactions with CDC28

Relevant genotype Sensitivity to 200 nM 1-NM-PP1 
 CDC28 cdc28-as1 
WT − − 
Recombination   
mre11Δ − ++++ 
rad50Δ − ++++ 
rad51Δ − 
rad52Δ − +++ 
rad54Δ − − 
pol32Δ − ++++ 
sae2Δ − 
RPA complex   
rfa1-t6 − ++++ 
rfa1-t11 − ++++ 
rfa1-t19 − ++++ 
rfa1-t48 − ++++ 
NHEJ   
yku80Δ − 
lig4Δ − − 
Replication fork progression   
top3Δ − 
sgs1Δ − 
rrm3Δ − − 
srs2Δ − − 
mus81Δ − − 
mus81Δ mms4Δ − − 
slx1Δ − +++ 
Nucleotide excision repair   
rad10Δ − − 
Okazaki fragments   
rnh201Δ rnh203Δ − − 
rad27Δ − ++++ 
Postreplication repair   
rad5Δ − ++ 
rad6Δ − ++++ 
rad18Δ − ++ 
pol30-119 − 
DNA damage and replication checkpoints   
rad17Δ − − 
rad24Δ − − 
rfc5-1 − 
elg1Δ − 
tof1Δ − 
csm3Δ − ++ 
mec1Δ − − 
tel1Δ − − 
mec1Δ tel1Δ − ++ 
rad53Δ − ++ 
chk1Δ − − 
Spindle checkpoint/ mitotic exit   
bub3Δ − ++++ 
mad2Δ − +++ 
bub2Δ − +++ 
Sister chromatid cohesion   
ctf4Δ − ++++ 
ctf18Δ − ++++ 
Chromatin organization   
asf1Δ − +++ 
cac1Δ − − 
Telomeres   
pif1Δ − − 
tlc1Δ − ++++ 
Oxidative stress response   
tsa1Δ − − 
Cdc28 regulation   
sic1Δ − − 
Relevant genotype Sensitivity to 200 nM 1-NM-PP1 
 CDC28 cdc28-as1 
WT − − 
Recombination   
mre11Δ − ++++ 
rad50Δ − ++++ 
rad51Δ − 
rad52Δ − +++ 
rad54Δ − − 
pol32Δ − ++++ 
sae2Δ − 
RPA complex   
rfa1-t6 − ++++ 
rfa1-t11 − ++++ 
rfa1-t19 − ++++ 
rfa1-t48 − ++++ 
NHEJ   
yku80Δ − 
lig4Δ − − 
Replication fork progression   
top3Δ − 
sgs1Δ − 
rrm3Δ − − 
srs2Δ − − 
mus81Δ − − 
mus81Δ mms4Δ − − 
slx1Δ − +++ 
Nucleotide excision repair   
rad10Δ − − 
Okazaki fragments   
rnh201Δ rnh203Δ − − 
rad27Δ − ++++ 
Postreplication repair   
rad5Δ − ++ 
rad6Δ − ++++ 
rad18Δ − ++ 
pol30-119 − 
DNA damage and replication checkpoints   
rad17Δ − − 
rad24Δ − − 
rfc5-1 − 
elg1Δ − 
tof1Δ − 
csm3Δ − ++ 
mec1Δ − − 
tel1Δ − − 
mec1Δ tel1Δ − ++ 
rad53Δ − ++ 
chk1Δ − − 
Spindle checkpoint/ mitotic exit   
bub3Δ − ++++ 
mad2Δ − +++ 
bub2Δ − +++ 
Sister chromatid cohesion   
ctf4Δ − ++++ 
ctf18Δ − ++++ 
Chromatin organization   
asf1Δ − +++ 
cac1Δ − − 
Telomeres   
pif1Δ − − 
tlc1Δ − ++++ 
Oxidative stress response   
tsa1Δ − − 
Cdc28 regulation   
sic1Δ − − 

−, not more sensitive/equally sensitive to cdc28-as1; +, slightly slower growth compared with cdc28-as1 single mutant; ++, slow growth compared with cdc28-as1 single mutant; +++, severely reduced growth compared with cdc28-as1 single mutant; ++++, near death or dead compared with cdc28-as1 single mutant.

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