Mutations in CDC28 suppress GCR rates
| Relevant genotype | Mutation rate (Canr − 5FOAr) (×10−10) | ||
| CDC28 | cdc28-as1 | cdc28-5M | |
| WT | 3.50 (1)a | <12.5 (<3.6)b | <128 (<37)b |
| CKIs | |||
| sic1Δ | 59.5 (17) | NT | NT |
| far1Δ | 71.1 (20) | NT | NT |
| sic1Δ far1Δ | 115.9 (33) | NT | NT |
| swe1Δ | <5.69 (<1.6)b | NT | NT |
| HR | |||
| rad50Δ | 2,300 (657)a | 148 (42) | NT |
| mre11Δ | 2,490 (711) | 128 (37) | <327 (93)b |
| mre11Δ in nocodazoleg | 5,700 (1,622) | NT | NT |
| mre11Δ in SC, RTh | 1,890 (543) | NT | NT |
| mre11Δ yku80Δ | 6,156 (1,759) | 542 (155) | NT |
| rad52Δ | 350 (100)c | 290 (83) | <446 (127)b |
| sae2Δ | 177 (51) | <67 (<19)b | NT |
| sae2Δ mre11Δ | 2,798 (797) | NT | NT |
| DNA damage and replication checkpoint | |||
| mec1Δ | 680 (194)d | NT | <33 (<9)b |
| mec1Δ tel1Δ | 45,000 (12,857)d | NT | 2,390 (683) |
| rad53Δ | 95 (27)d | <9.6 (<2.7)b | NT |
| pds1Δ | 670 (190)d | <64 (<18)b | NT |
| rfc5-1Δ | 660 (189)d | <5.1 (<1.5)b | NT |
| rad17Δ | 30 (9)d | <14 (<4)b | NT |
| rad24Δ | 40 (11)d | <26 (<7.4)b | NT |
| Others | |||
| sgs1Δ | 77 (22)e | 60 (17) | <74 (<21)b |
| rfa1-t11 (CEN) | 420 (120)a | <69 (<20)b | NT |
| rad27Δ | 4,400 (1,257)e | NT | <277 (<79)b |
| tsa1Δ | 173 (49)f | NT | <84 (24)b |
| pif1Δ | 3,530 (1,008)c | 519 (148) | 200 (57) |
| Relevant genotype | Mutation rate (Canr − 5FOAr) (×10−10) | ||
| CDC28 | cdc28-as1 | cdc28-5M | |
| WT | 3.50 (1)a | <12.5 (<3.6)b | <128 (<37)b |
| CKIs | |||
| sic1Δ | 59.5 (17) | NT | NT |
| far1Δ | 71.1 (20) | NT | NT |
| sic1Δ far1Δ | 115.9 (33) | NT | NT |
| swe1Δ | <5.69 (<1.6)b | NT | NT |
| HR | |||
| rad50Δ | 2,300 (657)a | 148 (42) | NT |
| mre11Δ | 2,490 (711) | 128 (37) | <327 (93)b |
| mre11Δ in nocodazoleg | 5,700 (1,622) | NT | NT |
| mre11Δ in SC, RTh | 1,890 (543) | NT | NT |
| mre11Δ yku80Δ | 6,156 (1,759) | 542 (155) | NT |
| rad52Δ | 350 (100)c | 290 (83) | <446 (127)b |
| sae2Δ | 177 (51) | <67 (<19)b | NT |
| sae2Δ mre11Δ | 2,798 (797) | NT | NT |
| DNA damage and replication checkpoint | |||
| mec1Δ | 680 (194)d | NT | <33 (<9)b |
| mec1Δ tel1Δ | 45,000 (12,857)d | NT | 2,390 (683) |
| rad53Δ | 95 (27)d | <9.6 (<2.7)b | NT |
| pds1Δ | 670 (190)d | <64 (<18)b | NT |
| rfc5-1Δ | 660 (189)d | <5.1 (<1.5)b | NT |
| rad17Δ | 30 (9)d | <14 (<4)b | NT |
| rad24Δ | 40 (11)d | <26 (<7.4)b | NT |
| Others | |||
| sgs1Δ | 77 (22)e | 60 (17) | <74 (<21)b |
| rfa1-t11 (CEN) | 420 (120)a | <69 (<20)b | NT |
| rad27Δ | 4,400 (1,257)e | NT | <277 (<79)b |
| tsa1Δ | 173 (49)f | NT | <84 (24)b |
| pif1Δ | 3,530 (1,008)c | 519 (148) | 200 (57) |
NT, not tested. Numbers in parentheses indicate fold increase over WT. The mutation rates are shown as events per generation.
Data from Chen and Kolodner (1999).
GCR rates could not be accurately calculated because GCRs were not detected in a large enough proportion of the cultures.
Data from Myung et al. (2001a).
Data from Myung et al. (2001c).
Data from Myung et al. (2001b).
Data from Huang and Kolodner (2005).
mre11Δ mutants were grown in 10 µM nocodazole until stationary phase to test the effect of delaying the cell cycle on GCR rates.
mre11Δ mutants were grown in synthetic complete medium (SC) at RT until stationary phase to test the effect of delaying the cell cycle on GCR rates.