Clinical features of active EAE in XX ovariectomized female C57BL/6 mice compared with XY− ovariectomized female C57BL/6 mice and XXSry castrated male C57BL/6 mice compared with XY−Sry castrated male C57BL/6 mice
| Genotype . | Incidence . | Mortality . | Mean day of onset . | Mean peak . | Mean score (all days) . |
|---|---|---|---|---|---|
| Experiment 1 | |||||
| XX females | 7/7 | 0/7 | 11 | 3.4 | 2.8 |
| XY− females | 6/6 | 0/6 | 13 | 3.2 | 2.1 |
| Experiment 2a | |||||
| XX females | 6/6 | 1/6 | 12 | 3.7 | 2.8 |
| XY− females | 4/4 | 1/4 | 9 | 3.9 | 3.0 |
| Experiment 3a | |||||
| XX Sry males | 6/6 | 0/6 | 11 | 4.4 | 3.4 |
| XY− Sry males | 6/6 | 0/6 | 13 | 4.5 | 3.3 |
| Experiment 4 | |||||
| XX Sry males | 5/5 | 0/5 | 14 | 2.9 | 2.3 |
| XY− Sry males | 7/7 | 0/7 | 14 | 3.6 | 2.9 |
| Experiment 5 | |||||
| XX Sry males | 5/5 | 3/5 | 14 | 4.7 | 3.0 |
| XY− Sry males | 7/7 | 4/7 | 12 | 4.4 | 3.0 |
| Genotype . | Incidence . | Mortality . | Mean day of onset . | Mean peak . | Mean score (all days) . |
|---|---|---|---|---|---|
| Experiment 1 | |||||
| XX females | 7/7 | 0/7 | 11 | 3.4 | 2.8 |
| XY− females | 6/6 | 0/6 | 13 | 3.2 | 2.1 |
| Experiment 2a | |||||
| XX females | 6/6 | 1/6 | 12 | 3.7 | 2.8 |
| XY− females | 4/4 | 1/4 | 9 | 3.9 | 3.0 |
| Experiment 3a | |||||
| XX Sry males | 6/6 | 0/6 | 11 | 4.4 | 3.4 |
| XY− Sry males | 6/6 | 0/6 | 13 | 4.5 | 3.3 |
| Experiment 4 | |||||
| XX Sry males | 5/5 | 0/5 | 14 | 2.9 | 2.3 |
| XY− Sry males | 7/7 | 0/7 | 14 | 3.6 | 2.9 |
| Experiment 5 | |||||
| XX Sry males | 5/5 | 3/5 | 14 | 4.7 | 3.0 |
| XY− Sry males | 7/7 | 4/7 | 12 | 4.4 | 3.0 |
These data are depicted in Fig. 3.