Table I.

PbA-induced experimental CM is associated with the presence of the C5 gene

Strain
C5 status
CM phenotypea
C57BL/6 Sufficient Susceptible 
C57BL/10 Sufficient Susceptible 
CBA/Ca Sufficient Susceptible 
DBA/1 Sufficient Susceptible 
SJL/J Sufficient Susceptible 
129sv/J Sufficient Highly susceptible 
129P3/J Sufficient Highly susceptible 
C3H/HeN Sufficient Susceptible 
B10.D2/nSnJ Sufficient Susceptible 
B10.D2/oSnJ Deficient Resistant 
A/J Deficient Resistant 
DBA/2 Deficient Resistant 
AKR/J Deficient Highly resistant 
BALB/c Sufficient Highly resistant 
Strain
C5 status
CM phenotypea
C57BL/6 Sufficient Susceptible 
C57BL/10 Sufficient Susceptible 
CBA/Ca Sufficient Susceptible 
DBA/1 Sufficient Susceptible 
SJL/J Sufficient Susceptible 
129sv/J Sufficient Highly susceptible 
129P3/J Sufficient Highly susceptible 
C3H/HeN Sufficient Susceptible 
B10.D2/nSnJ Sufficient Susceptible 
B10.D2/oSnJ Deficient Resistant 
A/J Deficient Resistant 
DBA/2 Deficient Resistant 
AKR/J Deficient Highly resistant 
BALB/c Sufficient Highly resistant 
a

CM phenotype describes mice that were judged as developing CM if they displayed neurological symptoms including mono-, hemi-, para-, or tetraplegia, movement disorder, ataxia, hunching, convulsions, and coma, and succumbed to infection by day 12 after inoculation (references 6, 7). Susceptible strains developed neurological symptoms within 6–10 d after inoculation. Highly susceptible mice showed both a significantly higher parasite density and an early onset of neurological symptoms and death than susceptible mouse strains. Resistant strains displayed a significantly delayed onset of neurological symptoms and improved survival compared with susceptible groups. Highly resistant strains did not develop neurological symptoms and displayed enhanced survival compared with resistant strains. Strains analyzed in this study are bolded. Other strains (italicized) were derived as previously described (references 26–28).

or Create an Account

Close Modal
Close Modal