Table I.

Architecture of BKV NCCR in plasma and urine of KT patients

Patients
Samples
rr-NCCR architecture in samples
Matched     plasma + urine  NCCR
 		 P valuea
 		 NCCR
 		 P valued
 		    
  ww rr   ww rr  ins ins/ww del del/ww 
Plasma n = 129 85b 44 b <0.0005 n = 286 222c 64c  9 4 27 24 
Percentage (%)  66 34   78 22  14 6 42 38 
PVAN n = 70 35 35          
Percentage (%)  50 50 <0.0005         
Viral load (geq/ml)      1.97 × 104e 4.36 × 105f <2 × 10−6     
25th percentile      3.93 × 103 6.59 × 104      
75th percentile      1.72 × 105 5.47 × 106      
Urine n = 129 119b 10b =0.45  274c 12c  - 2 5 5 
Percentage (%)  92 8   96 4  0 16 42 42 
PVAN n = 70 67 3 =0.5         
Percentage (%)  96 4          
Viral load (geq/ml)      2.89 × 108e 2.56 × 107f =0.098     
25th percentile      1.66 × 107 2.84 × 106      
75th percentile      3.38 × 109 6.93 × 108      
Consecutive plasma     (2005–2006) n = 227 172 55 =0.004 n = 733 620 113  12 15 39 47 
Percentage (%)  76 24   85 15  11 13 35 41 
PVAN n = 57 31 26 <0.002         
Percentage (%)  54 46          
Viral load (geq/ml)      1.94 × 104 4.59 × 105 <2 × 10−6     
25th percentile      4.55 × 103 3.51 × 105      
75th percentile      1.58 × 105 3.04 × 106      
Patients
Samples
rr-NCCR architecture in samples
Matched     plasma + urine  NCCR
 		 P valuea
 		 NCCR
 		 P valued
 		    
  ww rr   ww rr  ins ins/ww del del/ww 
Plasma n = 129 85b 44 b <0.0005 n = 286 222c 64c  9 4 27 24 
Percentage (%)  66 34   78 22  14 6 42 38 
PVAN n = 70 35 35          
Percentage (%)  50 50 <0.0005         
Viral load (geq/ml)      1.97 × 104e 4.36 × 105f <2 × 10−6     
25th percentile      3.93 × 103 6.59 × 104      
75th percentile      1.72 × 105 5.47 × 106      
Urine n = 129 119b 10b =0.45  274c 12c  - 2 5 5 
Percentage (%)  92 8   96 4  0 16 42 42 
PVAN n = 70 67 3 =0.5         
Percentage (%)  96 4          
Viral load (geq/ml)      2.89 × 108e 2.56 × 107f =0.098     
25th percentile      1.66 × 107 2.84 × 106      
75th percentile      3.38 × 109 6.93 × 108      
Consecutive plasma     (2005–2006) n = 227 172 55 =0.004 n = 733 620 113  12 15 39 47 
Percentage (%)  76 24   85 15  11 13 35 41 
PVAN n = 57 31 26 <0.002         
Percentage (%)  54 46          
Viral load (geq/ml)      1.94 × 104 4.59 × 105 <2 × 10−6     
25th percentile      4.55 × 103 3.51 × 105      
75th percentile      1.58 × 105 3.04 × 106      
a

Kolmogorov-Smirnov Goodness-of-Fit test (one-sided).

b,c

χ2 test (two-sided), plasma rr-NCCR versus urine rr-NCCR. P < 10−4.

d,e,f

Mann-Whitney U test (one-sided).

e

Plasma ww-NCCR versus urine ww-NCCR. P < 10−4.

f

Plasma rr-NCCR versus urine rr-NCCR. P < 0.002. Viral load is given as median.

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