Summary of immunizations and incidence of arthritis in DR4-IE tg and B6 mice
| Mouse strain | Immunizing antigen | Mice immunized | Arthritic mice |
|---|---|---|---|
| % | |||
| DR4-IE tg | CithFib | 135 | 48 (35.5) |
| DR4-IE tg | hFib | 24 | 0 |
| DR4-IE tg | CitmFib | 14 | 0 |
| DR4-IE tg | mFib | 14 | 0 |
| DR4-IE tg | CitKLH | 8 | 0 |
| B6 | CithFib | 14 | 0 |
| B6 | hFib | 14 | 0 |
| B6 | CitmFib | 8 | 0 |
| B6 | mFib | 8 | 0 |
| Mouse strain | Immunizing antigen | Mice immunized | Arthritic mice |
|---|---|---|---|
| DR4-IE tg | CithFib | 135 | 48 (35.5) |
| DR4-IE tg | hFib | 24 | 0 |
| DR4-IE tg | CitmFib | 14 | 0 |
| DR4-IE tg | mFib | 14 | 0 |
| DR4-IE tg | CitKLH | 8 | 0 |
| B6 | CithFib | 14 | 0 |
| B6 | hFib | 14 | 0 |
| B6 | CitmFib | 8 | 0 |
| B6 | mFib | 8 | 0 |
Immunizations were conducted as outlined in Materials and methods. All mice were observed for at least 70 d after primary immunization, with the maximum observation period for some groups being 200 d.