Table I.

Summary of immunizations and incidence of arthritis in DR4-IE tg and B6 mice

Mouse strain
Immunizing antigen
Mice immunized
Arthritic mice
   % 
DR4-IE tg CithFib 135 48 (35.5) 
DR4-IE tg hFib 24 
DR4-IE tg CitmFib 14 
DR4-IE tg mFib 14 
DR4-IE tg CitKLH 
B6 CithFib 14 
B6 hFib 14 
B6 CitmFib 
B6 mFib 
Mouse strain
Immunizing antigen
Mice immunized
Arthritic mice
   % 
DR4-IE tg CithFib 135 48 (35.5) 
DR4-IE tg hFib 24 
DR4-IE tg CitmFib 14 
DR4-IE tg mFib 14 
DR4-IE tg CitKLH 
B6 CithFib 14 
B6 hFib 14 
B6 CitmFib 
B6 mFib 

Immunizations were conducted as outlined in Materials and methods. All mice were observed for at least 70 d after primary immunization, with the maximum observation period for some groups being 200 d.

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