Arthritis development following TnfΔARE BM reconstitution of lethally irradiated recipients
| Donor genotype . | Recipient genotype . | Arthritis development . |
|---|---|---|
| WT | WT | 0/20 |
| TnfΔARE/+ | WT | 19/21 |
| TnfΔARE/ΔARE TnfRI−/− | WT | 25/25 |
| TnfΔARE/+ | TnfRI−/− | 0/8 |
| Donor genotype . | Recipient genotype . | Arthritis development . |
|---|---|---|
| WT | WT | 0/20 |
| TnfΔARE/+ | WT | 19/21 |
| TnfΔARE/ΔARE TnfRI−/− | WT | 25/25 |
| TnfΔARE/+ | TnfRI−/− | 0/8 |
BM isolated from 2-mo-old female B6,129 mice (donor genotype) was engrafted into 6–8-wk-old syngeneic, lethally irradiated, female mice (recipient genotype). Assessment of arthritis development was based on histopathological evaluation of joint samples at 12 wk after transfer.