Table I. GEP genes Functional group Gene... | Rockefeller University Press

Table I.

GEP genes

Functional group	Gene	ORF	Localization	Genetic interaction
Respiratory chain assembly	YTA10^a	YER017c	IM	SL
	YTA12^a	YMR089c	IM	SL
	YME1	YPR024w	IM	SL
	OXA1	YER154w	IM	GD
	COX6	YHR051w	IM	GD
	COX24	YLR204w	IM	GD
	ATP7	YKL016c	IM	GD
	ATP10^a	YLR292w	IM	GD
	ATP17	YDR377w	IM	GD
	ATP23^a	YNR020c	IMS	GD
	COQ1	YBR003w	MA	GD
Mitochondrial morphology/β-barrel assembly	MMM1^a^b	YLL006w	IM/OM	SL
	MDM10^a^b	YAL010c	OM	SL
	MDM12^a^b	YOL009c	OM	GD
	MDM31^b	YHR194w	IM	GD
	MDM32^b	YOR147w	IM	SL
	MDM34^b	YGL219c	OM	SL
	MDM35	YKL053c-A	IMS	SL
	UPS1^b	YLR193c	IMS	SL
Unknown	GEP1	YLR168c	IMS	SL
	GEP3	YOR205c	M	GD
	GEP4	YHR100c	M	SL
	GEP5	YLR091w	M	GD
	GEP6	YMR293c	M	SL
	GEP7	YGL057c	M	GD
	GEP8	YER093c-A	ND	SL
	GEP9	YNL170w	ND	SL
Diverse	PSD1^a	YNL169c	IM	SL
	CRD1^b	YDL142c	IM	SL
	HMI1	YOL095c	IM/MA	GD
	MRE11	YMR224c	M, N, C	GD
	CTK3	YML112w	N, C	GD
	PIF1	YML061c	M, N	GD
	PIH1	YHR034c	N	GD
	EMI1	YDR512c	C	GD

Functional group	Gene	ORF	Localization	Genetic interaction
Respiratory chain assembly	YTA10^a	YER017c	IM	SL
	YTA12^a	YMR089c	IM	SL
	YME1	YPR024w	IM	SL
	OXA1	YER154w	IM	GD
	COX6	YHR051w	IM	GD
	COX24	YLR204w	IM	GD
	ATP7	YKL016c	IM	GD
	ATP10^a	YLR292w	IM	GD
	ATP17	YDR377w	IM	GD
	ATP23^a	YNR020c	IMS	GD
	COQ1	YBR003w	MA	GD
Mitochondrial morphology/β-barrel assembly	MMM1^a^b	YLL006w	IM/OM	SL
	MDM10^a^b	YAL010c	OM	SL
	MDM12^a^b	YOL009c	OM	GD
	MDM31^b	YHR194w	IM	GD
	MDM32^b	YOR147w	IM	SL
	MDM34^b	YGL219c	OM	SL
	MDM35	YKL053c-A	IMS	SL
	UPS1^b	YLR193c	IMS	SL
Unknown	GEP1	YLR168c	IMS	SL
	GEP3	YOR205c	M	GD
	GEP4	YHR100c	M	SL
	GEP5	YLR091w	M	GD
	GEP6	YMR293c	M	SL
	GEP7	YGL057c	M	GD
	GEP8	YER093c-A	ND	SL
	GEP9	YNL170w	ND	SL
Diverse	PSD1^a	YNL169c	IM	SL
	CRD1^b	YDL142c	IM	SL
	HMI1	YOL095c	IM/MA	GD
	MRE11	YMR224c	M, N, C	GD
	CTK3	YML112w	N, C	GD
	PIF1	YML061c	M, N	GD
	PIH1	YHR034c	N	GD
	EMI1	YDR512c	C	GD

C, cytosol; GD, growth defect associated with double mutant; IM, inner membrane; IMS, intermembrane space; M, mitochondria; MA, matrix; N, nucleus; ND, not determined; OM, outer membrane; SL, synthetically lethal.

Previously described synthetic lethal interactions (Berger and Yaffe, 1998; Steglich et al., 1999; Birner et al., 2003; Osman et al., 2007).

Genetic interactors identified by sporulation and tetrad dissection only.

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