Table I. Assessment of left ventricular... | Rockefeller University Press

Table I.

Assessment of left ventricular size and function

Parameter	MCM⁻;Rb^L/L;p130^+/+	MCM⁺;Rb^L/L;p130^+/+	MCM⁻;Rb^L/L;p130^−/−	MCM⁺;Rb^L/L;p130^−/−
TAM	+	+	+	+
HR (bpm)	477 ± 6	473 ± 14	475 ± 16	480 ± 12
EF (%)	56.13 ± 2.02	50.40 ± 2.65	56.39 ± 3.32	33.52 ± 2.81^a
FS (%)	28.88 ± 1.29	25.32 ± 1.59	29.13 ± 2.31	15.97 ± 1.50^a
LVID;d (mm)	3.87 ± 0.07	3.98 ± 0.15	3.76 ± 0.02	4.78 ± 0.28^a
LVID;s (mm)	2.74 ± 0.08	2.98 ± 0.16	2.67 ± 0.08	4.02 ± 0.28^a
LVPW;d (mm)	0.63 ± 0.03	0.65 ± 0.14	0.67 ± 0.02	0.78 ± 0.03^a
LVPW;s (mm)	0.89 ± 0.02	0.89 ± 0.03	0.89 ± 0.02	0.78 ± 0.03^a

Parameter	MCM⁻;Rb^L/L;p130^+/+	MCM⁺;Rb^L/L;p130^+/+	MCM⁻;Rb^L/L;p130^−/−	MCM⁺;Rb^L/L;p130^−/−
TAM	+	+	+	+
HR (bpm)	477 ± 6	473 ± 14	475 ± 16	480 ± 12
EF (%)	56.13 ± 2.02	50.40 ± 2.65	56.39 ± 3.32	33.52 ± 2.81^a
FS (%)	28.88 ± 1.29	25.32 ± 1.59	29.13 ± 2.31	15.97 ± 1.50^a
LVID;d (mm)	3.87 ± 0.07	3.98 ± 0.15	3.76 ± 0.02	4.78 ± 0.28^a
LVID;s (mm)	2.74 ± 0.08	2.98 ± 0.16	2.67 ± 0.08	4.02 ± 0.28^a
LVPW;d (mm)	0.63 ± 0.03	0.65 ± 0.14	0.67 ± 0.02	0.78 ± 0.03^a
LVPW;s (mm)	0.89 ± 0.02	0.89 ± 0.03	0.89 ± 0.02	0.78 ± 0.03^a

2D echocardiographic analysis of left ventricle function in mice with the indicated genotypes 4 wk after TAM treatment. n = 5 mice per group. Results are presented as the mean ± SEM. HR, heart rate; EF, ejection fraction; FS, fractional shortening; LVID;d/s, left ventricular internal dimension in diastole/systole; LVPW;d/s, left ventricular posterior wall thickness in diastole/systole.

P < 0.05 by analysis of variance for MCM⁻;Rb^L/L;p130^+/+, MCM⁺;Rb^L/L;p130^+/+, and MCM⁻;Rb^L/L;p130^−/− versus MCM⁺;Rb^L/L;p130^−/− littermates.

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