Gradual overexpression of UbcH10 in splenocytes leads to progressive aneuploidy
| Mouse genotype | Age | Aneuploid figures (SD) | Karyotypes with indicated chromosome number | Mitotic figures with PMSCS (SD) | |||||
| 37 | 38 | 39 | 40 | 41 | 42 | ||||
| mo | % | % | |||||||
| +/+ | 5 | 0 (0) | 150 | 0 (0) | |||||
| UbcH10T1 | 5 | 4 (0) | 1 | 144 | 4 | 1 | 0 (0) | ||
| UbcH10T2 | 5 | 6 (2) | 1 | 2 | 3 | 141 | 3 | 1 (1) | |
| UbcH10T1/T1 | 5 | 13 (1) | 2 | 4 | 130 | 12 | 2 | 4 (1) | |
| UbcH10T2/T2 | 5 | 19 (1) | 1 | 3 | 9 | 121 | 13 | 3 | 5 (1) |
| Mouse genotype | Age | Aneuploid figures (SD) | Karyotypes with indicated chromosome number | Mitotic figures with PMSCS (SD) | |||||
| 37 | 38 | 39 | 40 | 41 | 42 | ||||
| +/+ | 5 | 0 (0) | 150 | 0 (0) | |||||
| 5 | 4 (0) | 1 | 144 | 4 | 1 | 0 (0) | |||
| 5 | 6 (2) | 1 | 2 | 3 | 141 | 3 | 1 (1) | ||
| 5 | 13 (1) | 2 | 4 | 130 | 12 | 2 | 4 (1) | ||
| 5 | 19 (1) | 1 | 3 | 9 | 121 | 13 | 3 | 5 (1) | |
Of each genotype, 50 spreads from three individual mice were counted. Empty cells indicate that there were no karyotypes with the indicated chromosome number.
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