Yeast two-hybrid interactions between lobe A COG components and Atg proteins
| Subunit | Atg5 | Atg7 | Atg8 | Atg9 | Atg11 | Atg12 | Atg13 | Atg16 | Atg17 | Atg18 | Atg20 | Atg24 |
| Cog1 | − | − | − | − | − | − | − | − | +++ | − | + | ++ |
| Cog2 | − | − | − | − | − | +++ | − | − | ++ | − | ++ | ++ |
| Cog3 | − | − | − | + | − | − | − | − | +++ | − | + | ++ |
| Cog4 | − | − | − | + | − | − | − | − | +++ | − | ++ | ++ |
| Subunit | Atg5 | Atg7 | Atg8 | Atg9 | Atg11 | Atg12 | Atg13 | Atg16 | Atg17 | Atg18 | Atg20 | Atg24 |
| Cog1 | − | − | − | − | − | − | − | − | +++ | − | + | ++ |
| Cog2 | − | − | − | − | − | +++ | − | − | ++ | − | ++ | ++ |
| Cog3 | − | − | − | + | − | − | − | − | +++ | − | + | ++ |
| Cog4 | − | − | − | + | − | − | − | − | +++ | − | ++ | ++ |
The interaction strength is scored by the number of pluses: +, grows weakly on plates lacking histidine; ++, growth on plates lacking histidine but not on plates lacking adenine; +++, growth on plates lacking adenine; −, no growth. All the interactions were scored after growth for 3 d at 30°C.