Table I.

Parameters used in the merotelic model

Notation Definition Adimensionalized value Value 
General    
    N Number of merotelic Kts 1–4 NA 
    Mk Maximum number of Kt–MTs per side NA 
Geometry    
    L0 Spindle initial length 2–6 2–6 µm 
    do Equilibrium distance between attachment sites 0.01 0.01 µm 
Mechanical    
    κ Centromere spring constant 20 pN/µm 
    µs SPB friction coefficient 1.4 420 pN.s/µm 
    µk Centromere friction coefficient 300 pN.s/µm 
    µc Sister chromatid friction coefficient 0.2 60 pN.s/µm 
Motors    
    Fk Kt force generators stall force 10 pN 
    Vk Kt force generators maximum speed 310−2 µm/s 
    Fmz Midzone force generators stall force 70 pN 
    Vmz Midzone force generators maximum speed 0.4 1.210−2 µm/s 
Dynamic instability    
    fa Attachment frequency 0.04 0.04 1/s 
    fd Detachment frequency 0.1 0.1 1/s 
Notation Definition Adimensionalized value Value 
General    
    N Number of merotelic Kts 1–4 NA 
    Mk Maximum number of Kt–MTs per side NA 
Geometry    
    L0 Spindle initial length 2–6 2–6 µm 
    do Equilibrium distance between attachment sites 0.01 0.01 µm 
Mechanical    
    κ Centromere spring constant 20 pN/µm 
    µs SPB friction coefficient 1.4 420 pN.s/µm 
    µk Centromere friction coefficient 300 pN.s/µm 
    µc Sister chromatid friction coefficient 0.2 60 pN.s/µm 
Motors    
    Fk Kt force generators stall force 10 pN 
    Vk Kt force generators maximum speed 310−2 µm/s 
    Fmz Midzone force generators stall force 70 pN 
    Vmz Midzone force generators maximum speed 0.4 1.210−2 µm/s 
Dynamic instability    
    fa Attachment frequency 0.04 0.04 1/s 
    fd Detachment frequency 0.1 0.1 1/s 

NA, not applicable. Value is determined with Fk at 10 pN and Vk at 0.03 µm/s.

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