Table I.

SV and DCV statistics

Genotype Number of profiles/animals analyzed Mean synaptic area SV/profile Mean diameter of SVs DCV/profile Mean diameter of DCVs 
  µm2  nm  nm 
Wild type 30/5 0.25 ± 0.02 34.9 ± 2.4 30.3 ± 0.7 2.0 ± 0.2 44.8 ± 1.0 
unc-108(n777) 34/4 0.20 ± 0.01 39.3 ± 1.8 28.4 ± 0.7 2.0 ± 0.2a 54.1 ± 3.4c 
unc-108(n501) 31/4 0.23 ± 0.03 38.7 ± 1.7 27.7 ± 0.5 2.3 ± 0.3a 49.4 ± 2.3b 
unc-108(ce363) 28/3 0.25 ± 0.02 35.1 ± 2.8 30.3 ± 0.7 1.2 ± 0.3b 71.8 ± 3.4d 
unc-108(nu415) 26/4 0.21 ± 0.01 29.2 ± 1.5 26.6 ± 0.6 1.7 ± 0.4a 46.9 ± 2.0a 
ric-19(ok833) 32/4 0.22 ± 0.01 33.1 ± 1.3 27.2 ± 0.6 2.7 ± 0.4a 42.0 ± 2.0a 
rab-3(js49) 13/3 0.22 ± 0.02 37.7 ± 3.4 27.8 ± 0.6 3.2 ± 0.5b 41.7 ± 1.1b 
Genotype Number of profiles/animals analyzed Mean synaptic area SV/profile Mean diameter of SVs DCV/profile Mean diameter of DCVs 
  µm2  nm  nm 
Wild type 30/5 0.25 ± 0.02 34.9 ± 2.4 30.3 ± 0.7 2.0 ± 0.2 44.8 ± 1.0 
unc-108(n777) 34/4 0.20 ± 0.01 39.3 ± 1.8 28.4 ± 0.7 2.0 ± 0.2a 54.1 ± 3.4c 
unc-108(n501) 31/4 0.23 ± 0.03 38.7 ± 1.7 27.7 ± 0.5 2.3 ± 0.3a 49.4 ± 2.3b 
unc-108(ce363) 28/3 0.25 ± 0.02 35.1 ± 2.8 30.3 ± 0.7 1.2 ± 0.3b 71.8 ± 3.4d 
unc-108(nu415) 26/4 0.21 ± 0.01 29.2 ± 1.5 26.6 ± 0.6 1.7 ± 0.4a 46.9 ± 2.0a 
ric-19(ok833) 32/4 0.22 ± 0.01 33.1 ± 1.3 27.2 ± 0.6 2.7 ± 0.4a 42.0 ± 2.0a 
rab-3(js49) 13/3 0.22 ± 0.02 37.7 ± 3.4 27.8 ± 0.6 3.2 ± 0.5b 41.7 ± 1.1b 

SV and DCV numbers and diameters are as determined by HPF EM. DCV statistics of unc-108 mutants are compared with wild type (Student's t test).

a

NS.

b

P < 0.05.

c

P < 0.01.

d

P < 0.005.

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