Curve fit parameters for selected Qc and Sec17 dose-response relationships
| Protein | Figure | Experimental condition | EC50 | IC50 | Hill coefficient | r2 |
| nM | nM | |||||
| Qcwt | 2 A | No ATP (priming bypass) | 3.74 ± 0.66 | NA | 1.04 ± 0.15 | 0.979 |
| Qc7Δ | 2 A | No ATP (priming bypass) | 0.55 ± 0.07 | NA | 1.03 ± 0.11 | 0.982 |
| Qc5Δ | 2 A | No ATP (priming bypass) | 1.05 ± 0.15 | NA | 0.96 ± 0.11 | 0.982 |
| Qc3Δ | 2 A | No ATP (priming bypass) | 4.75 ± 0.53 | NA | 1.34 ± 0.16 | 0.989 |
| Qc5Δ | 2 C | +ATP (competition with wt) | NA | 28.9 ± 7.8 | −1.10 ± 0.25 | 0.947 |
| Qc3Δ | 2 C | +ATP (competition with wt) | NA | 40.6 ± 3.4 | −1.30 ± 0.12 | 0.996 |
| Qc1Δ | 2 C and S1 | +ATP (competition with wt) | NA | 656 ± 110 | −0.70 ± 0.08 | 0.733 |
| QcΔSD | 2 C and S1 | +ATP (competition with wt) | NA | 417 ± 45 | −0.99 ± 0.10 | 0.841 |
| Qc GST-PX | S1 | +ATP (competition with wt) | NA | 2,010 ± 247 | −0.89 ± 0.09 | 0.892 |
| Qcwt | 6 A | No ATP, +94 nM Sec17 | 34.3 ± 4.8 | NA | 0.94 ± 0.08 | 0.997 |
| Qc7Δ | 6 A | No ATP, +94 nM Sec17 | 8.6 ± 1.1 | NA | 1.13 ± 0.16 | 0.990 |
| Qc5Δ | 6 A | No ATP, +94 nM Sec17 | 11.7 ± 1.2 | NA | 1.33 ± 0.13 | 0.996 |
| Qc3Δ | 6 A | No ATP, +94 nM Sec17 | 19.9 ± 1.6 | NA | 1.29 ± 0.07 | 0.999 |
| Sec17 wt | 6 C | No ATP, +75 nM Qc3Δ | 125 ± 3.0 | NA | 4.97 ± 0.46 | 0.995 |
| Sec17-LALA | 6 C | No ATP, +75 nM Qc3Δ | 158 ± 5.0 | NA | 4.30 ± 0.45 | 0.992 |
| His6-Sec17 | S1 | No ATP, +75 nM Qc3Δ | 41.0 ± 3.6 | NA | 5.71 ± 2.23 | 0.933 |
| Protein | Figure | Experimental condition | EC50 | IC50 | Hill coefficient | r2 |
| nM | nM | |||||
| Qcwt | 2 A | No ATP (priming bypass) | 3.74 ± 0.66 | NA | 1.04 ± 0.15 | 0.979 |
| Qc7Δ | 2 A | No ATP (priming bypass) | 0.55 ± 0.07 | NA | 1.03 ± 0.11 | 0.982 |
| Qc5Δ | 2 A | No ATP (priming bypass) | 1.05 ± 0.15 | NA | 0.96 ± 0.11 | 0.982 |
| Qc3Δ | 2 A | No ATP (priming bypass) | 4.75 ± 0.53 | NA | 1.34 ± 0.16 | 0.989 |
| Qc5Δ | 2 C | +ATP (competition with wt) | NA | 28.9 ± 7.8 | −1.10 ± 0.25 | 0.947 |
| Qc3Δ | 2 C | +ATP (competition with wt) | NA | 40.6 ± 3.4 | −1.30 ± 0.12 | 0.996 |
| Qc1Δ | 2 C and S1 | +ATP (competition with wt) | NA | 656 ± 110 | −0.70 ± 0.08 | 0.733 |
| QcΔSD | 2 C and S1 | +ATP (competition with wt) | NA | 417 ± 45 | −0.99 ± 0.10 | 0.841 |
| Qc GST-PX | S1 | +ATP (competition with wt) | NA | 2,010 ± 247 | −0.89 ± 0.09 | 0.892 |
| Qcwt | 6 A | No ATP, +94 nM Sec17 | 34.3 ± 4.8 | NA | 0.94 ± 0.08 | 0.997 |
| Qc7Δ | 6 A | No ATP, +94 nM Sec17 | 8.6 ± 1.1 | NA | 1.13 ± 0.16 | 0.990 |
| Qc5Δ | 6 A | No ATP, +94 nM Sec17 | 11.7 ± 1.2 | NA | 1.33 ± 0.13 | 0.996 |
| Qc3Δ | 6 A | No ATP, +94 nM Sec17 | 19.9 ± 1.6 | NA | 1.29 ± 0.07 | 0.999 |
| Sec17 wt | 6 C | No ATP, +75 nM Qc3Δ | 125 ± 3.0 | NA | 4.97 ± 0.46 | 0.995 |
| Sec17-LALA | 6 C | No ATP, +75 nM Qc3Δ | 158 ± 5.0 | NA | 4.30 ± 0.45 | 0.992 |
| His6-Sec17 | S1 | No ATP, +75 nM Qc3Δ | 41.0 ± 3.6 | NA | 5.71 ± 2.23 | 0.933 |
IC50, 50% inhibitory concentration; NA, not applicable; wt, wild type. Errors indicate ±SEM for fits to three or more independently obtained data sets.