Table II. Summary of gene expression and... | Rockefeller University Press

Table II.

Summary of gene expression and gene positioning data

	Day 0→day 20			Day 0→Q			Q→day 20			Day 0→day 20E
	Posn	Exp	Posn	Exp	Posn	Exp	Posn	Exp	Posn	Exp,	Posn	Exp
AKT1	In	NSD	In	↓	In	↑	In	NSD	P	NSD	NSD	NSD
BCL2	NSD	↓	NSD	↓	P	↑	P	↓	P	NSD	P	NSD
CCND1	In	↓	NSD	↓	In	↑	In	↓	NSD	NSD	In	↑
ERBB2	In	NSD	In	↑	In	NSD	In	↑	In	NSD	In	↑
ERBB2IP	NSD	↑	NSD	↑	In	NSD	NSD	↑	NSD	NSD	In	NSD
FGFR1	NSD	NSD	P	NSD	In	↓	P	NSD	NSD	↑	In	NSD
MMP1	In	↑	NSD	NSD	In	↑	In	↑	NSD	↑	In	↑
TP53	NSD	↑	NSD	NSD	NSD	↑	In	NSD	NSD	↓	In	NSD
PTEN	In	↑	In	↑	In	NSD	In	↑	NSD	↓	In	↓
TGFB3	Altered^{^a}	NSD	Altered^{^a}	NSD	NSD	NSD	Altered^{^a}	NSD	NSD	NSD	NSD	NSD
VEGF	In	↑	P	NSD	In	NSD	NSD	↑	P	NSD	In	↑

	Day 0→day 20			Day 0→Q			Q→day 20			Day 0→day 20E
	Posn	Exp	Posn	Exp	Posn	Exp	Posn	Exp	Posn	Exp,	Posn	Exp
AKT1	In	NSD	In	↓	In	↑	In	NSD	P	NSD	NSD	NSD
BCL2	NSD	↓	NSD	↓	P	↑	P	↓	P	NSD	P	NSD
CCND1	In	↓	NSD	↓	In	↑	In	↓	NSD	NSD	In	↑
ERBB2	In	NSD	In	↑	In	NSD	In	↑	In	NSD	In	↑
ERBB2IP	NSD	↑	NSD	↑	In	NSD	NSD	↑	NSD	NSD	In	NSD
FGFR1	NSD	NSD	P	NSD	In	↓	P	NSD	NSD	↑	In	NSD
MMP1	In	↑	NSD	NSD	In	↑	In	↑	NSD	↑	In	↑
TP53	NSD	↑	NSD	NSD	NSD	↑	In	NSD	NSD	↓	In	NSD
PTEN	In	↑	In	↑	In	NSD	In	↑	NSD	↓	In	↓
TGFB3	Altered^a	NSD	Altered^a	NSD	NSD	NSD	Altered^a	NSD	NSD	NSD	NSD	NSD
VEGF	In	↑	P	NSD	In	NSD	NSD	↑	P	NSD	In	↑

Heading row shows growth conditions being compared. Changes in gene positions (Posn) and in gene expression (Exp) between growth conditions are shown.

Day 0, proliferating 2D cultures; Day 20, control cultures grown in 3D culture for 20 d; Day 20E, ErbB2-activated 3D cultures; In, internal movement; NSD, no significant difference between the growth conditions; P, peripheral movement; Q, quiescent 2D cultures; ↑, up-regulation; ↓, down-regulation.

TGFB3 shifts from two subpopulations at day 0 to a single population distribution pattern in all other growth conditions.

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