Kinesin-2 motors transport IFT particles as cargo anterogradely along the cilium
| IFT motor activity | Pure motor | Motor in cilium | IFT particles | Assembly of: |
|---|---|---|---|---|
| μm/s | μm/s | μm/s | ||
| Kinesin-II (osm-3) | 0.4 | 0.5 | 0.5 | Middle segment |
| OSM-3 (klp-11 or kap-1) | 1.1 | 1.3 | 1.2 | Full-length cilium/distal segment |
| Kinesin-II and OSM-3 | 0.7 | 0.7 | 0.7 | Middle segment (redundant) |
| IFT motor activity | Pure motor | Motor in cilium | IFT particles | Assembly of: |
|---|---|---|---|---|
| Kinesin-II ( | 0.4 | 0.5 | 0.5 | Middle segment |
| OSM-3 ( | 1.1 | 1.3 | 1.2 | Full-length cilium/distal segment |
| Kinesin-II and OSM-3 | 0.7 | 0.7 | 0.7 | Middle segment (redundant) |
Results of in vivo transport assays performed in C. elegans sensory cilia combined with in vitro motility assays of purified kinesin-II and OSM-3. In the first column, the italicized text in parentheses refers to the mutant background for the in vivo assay of individual motor activity.
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