Table II.

Golgi-associated proteins with a role in regulating centrosome and spindle function

Protein Function Depletion phenotype Reference 
Sac1 Lipid phosphatase Multiple mechanically active spindles Liu et al., 2008  
GM130 Golgin Aberrant centrosome, multipolar spindles Kodani and Sütterlin, 2008  
GRASP65 Golgi matrix Multipolar spindles, mitotic cell death Sütterlin et al., 2005  
RINT-1 Membrane traffic Multipolar spindles, mitotic cell death Sun et al., 2007  
Tankyrase-1 ADP ribosyl transferase Multipolar spindles, mitotic cell death Chang et al., 2005  
Rab6′ GTPase Metaphase block, SAC activation Miserey-Lenkei et al., 2006  
Clathrin Vesicle coat Defects in chromosome congression, SAC activation Royle et al., 2005  
Protein Function Depletion phenotype Reference 
Sac1 Lipid phosphatase Multiple mechanically active spindles Liu et al., 2008  
GM130 Golgin Aberrant centrosome, multipolar spindles Kodani and Sütterlin, 2008  
GRASP65 Golgi matrix Multipolar spindles, mitotic cell death Sütterlin et al., 2005  
RINT-1 Membrane traffic Multipolar spindles, mitotic cell death Sun et al., 2007  
Tankyrase-1 ADP ribosyl transferase Multipolar spindles, mitotic cell death Chang et al., 2005  
Rab6′ GTPase Metaphase block, SAC activation Miserey-Lenkei et al., 2006  
Clathrin Vesicle coat Defects in chromosome congression, SAC activation Royle et al., 2005  

SAC, spindle assembly checkpoint.

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