Table I.

Telomerase deficiency does not further reduce the low birth rates of ATRS/S mice

Genotype Number of mice (percentage) 
ATR+/+/G3 Terc+/−* 18 (15.5) 
ATR+/+/G3 Terc−/−* 23 (19.8) 
ATR+/S/G3 Terc+/−* 30 (25.9) 
ATR+/S/G3 Terc−/−* 32 (27.6) 
ATRS/S/G3 Terc+/−* 7 (6.0) 
ATRS/S/G3 Terc−/−* 6 (5.2) 
Genotype Number of mice (percentage) 
ATR+/+/G3 Terc+/−* 18 (15.5) 
ATR+/+/G3 Terc−/−* 23 (19.8) 
ATR+/S/G3 Terc+/−* 30 (25.9) 
ATR+/S/G3 Terc−/−* 32 (27.6) 
ATRS/S/G3 Terc+/−* 7 (6.0) 
ATRS/S/G3 Terc−/−* 6 (5.2) 

Table indicates the number of mice born for each genotype from a total of 19 ATR+/S/Terc+/− × ATR+/S/G2 Terc−/− crosses. Statistical analysis using χ2 test is shown for comparison of G3 Terc+/−* versus G3 Terc−/−* for each ATR genotype. Parents were ATR+/S/Terc+/− × ATR+/S/G2 Terc−/−. Mean litter size was 4.8 pups. The total number of mice studied is 116. P = 0.435 comparing ATR+/+/G3 Terc+/−* with ATR+/+/G3 Terc−/−*; P = 0.799 comparing ATR+/S/G3 Terc+/−* with ATR+/S/G3 Terc−/−*; and P = 0.593 comparing ATRS/S/G3 Terc+/−* with ATRS/S/G3 Terc−/−*.

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