Table II. Modal chromosome number and... | Rockefeller University Press

Table II.

Modal chromosome number and percentage of nonmodal cells in subclones generated from p53-null clones induced to persistently missegregate chromosomes for 27 generations

Cell line	Mode (percent deviation)
	Chr 2	Chr 4	Chr 7	Chr 15
p53^−/− G subclone 1	2 (3.3)^a	2 (5.3)	2 (8.3)^a	2 (13.3)^a
p53^−/− H subclone 1	2 (3.3)	2 (11.3)^a	2 (9.0)^a	2 (9.0)^a
p53^−/− H subclone 2	2 (14.3)^a	2 (16.7)^a	2 (18.0)^a	2 (14.7)^a
p53^−/− H subclone 3	2 (10.3)^a	2 (11.0)^a	2 (14.0)^a	2 (13.0)^a
p53^−/− H subclone 4	2 (5.0)	2 (4.7)	2 (4.7)	2 (6.3)
p53^−/− I subclone 1	2 (8.7)^a	2 (16.7)^a	2 (11.7)^a	2 (12.3)^a
p53^−/− J subclone 1	2 (4.7)	2 (7.0)	2 (9.7)^a	2 (8.3)^a
p53^−/− J subclone 2	4 (55.3)^a	2 (67.3)^a	4 (62.0)^a	2 (51.0)^a

Cell line	Mode (percent deviation)
	Chr 2	Chr 4	Chr 7	Chr 15
p53^−/− G subclone 1	2 (3.3)^a	2 (5.3)	2 (8.3)^a	2 (13.3)^a
p53^−/− H subclone 1	2 (3.3)	2 (11.3)^a	2 (9.0)^a	2 (9.0)^a
p53^−/− H subclone 2	2 (14.3)^a	2 (16.7)^a	2 (18.0)^a	2 (14.7)^a
p53^−/− H subclone 3	2 (10.3)^a	2 (11.0)^a	2 (14.0)^a	2 (13.0)^a
p53^−/− H subclone 4	2 (5.0)	2 (4.7)	2 (4.7)	2 (6.3)
p53^−/− I subclone 1	2 (8.7)^a	2 (16.7)^a	2 (11.7)^a	2 (12.3)^a
p53^−/− J subclone 1	2 (4.7)	2 (7.0)	2 (9.7)^a	2 (8.3)^a
p53^−/− J subclone 2	4 (55.3)^a	2 (67.3)^a	4 (62.0)^a	2 (51.0)^a

Chr, chromosome. 300 nuclei were counted per chromosome per subclone.

Deviation from mode is statistically significant compared with p53^+/+ controls in Table I (P < 0.05, χ² test).

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